A major study suggests glucosamine, a popular supplement for joint pain, could be linked to faster progression from mild cognitive impairment to Alzheimer’s disease. Researchers found a 25% higher likelihood of developing dementia among glucosamine users and uncovered biological clues that may explain why.
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Researchers have identified a new Alzheimer’s target and created an experimental compound that blocks a damaging process inside brain cells. In mice, the treatment slowed nerve cell loss, reduced Alzheimer’s-related changes, and even appeared to promote healthier aging.
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Slowing the progression of Alzheimer’s disease is the goal of most existing treatments, but reversing it is much harder. That’s because once neurons are lost, the adult brain lacks the ability to replace them.
But new research, led by scientists at the University of South Carolina, has shown promise in regrowing neurons in brain organoids, and restoring cognition in mouse models of Alzheimer’s.
“After just two injections, these mice became smarter,” says Peisheng Xu, professor of pharmaceutics at the University of South Carolina and corresponding author of the new study, published in the journal Cell Biomaterials.
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In 2022, neurologists at a memory clinic in China diagnosed a 19-year-old with what they believed to be a probable case of Alzheimer’s – making him the youngest person ever to be diagnosed with the condition.
The teen first began experiencing memory decline around age 17, with symptoms worsening over time.
Brain scans revealed shrinkage in the hippocampus, a region involved in memory, while his cerebrospinal fluid showed biomarkers consistent with Alzheimer’s – the most common form of dementia.
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A single brain scan taking a static snapshot of brain tissue volume can forecast future cognitive decline better than tracking brain shrinkage over time. This approach offers a practical way to identify people at risk for dementia by assessing their brain’s built-in structural reserve. The research was published in Cortex.
As people grow older, they can accumulate physical damage inside their brains caused by diseases like Alzheimer’s. Yet, individuals with similar amounts of this microscopic damage often experience vastly different levels of memory loss. Some older adults maintain relatively sharp thinking skills despite harboring the physiological hallmarks of dementia.
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