Disrupted sleep is common in late life, the study authors wrote, and associated with changes in cognitive function — the mental capacity for learning, thinking, reasoning, problem-solving, decision-making, remembering and paying attention.Age-related changes in sleep have also been linked with early signs of Alzheimer’s disease, depression and cardiovascular disease, so the authors investigated possible associations between self-reported sleep duration, demographic and lifestyle factors, subjective and objective cognitive function, and participants’ levels of beta amyloid.
According to a US study published on Brain Plasticity, “Compared to traditional forms of aerobic and anaerobic exercise, the relatively low-impact, modifiable nature of yoga can offer a middle ground for individuals with movement limitations, clinical diagnoses, and is particularly suitable for aging populations. Yoga’s focus on improving the self through both physical and mental practices incorporates more mindful elements absent in traditional forms of exercise.”
Research on the Mediterranean diet has found it to have a number of health benefits. A recent study, published in Experimental Gerontology, found that daily consumption of extra virgin olive oil (EVOO), an essential component of the Mediterranean diet, might be the key to helping the body fight Alzheimer’s.
Swiss biopharma AC Immune has made targeting Alzheimer’s disease, the leading form of dementia, a top priority. The company’s numerous candidates and platforms target several different proteins and pathways thought to have a central role in Alzheimer’s pathology. 2020 has brought mixed news for AC Immune. In July, the company announced that their candidate tau vaccine, ACI-35.030, had shown “encouraging” safety data at a lower dose and was to be progressed to a higher-dose group. However, September brought the disappointing news that their anti-tau antibody, semorinemab, did not meet its primary efficacy endpoints in a Phase 2 trial. To discuss AC Immune’s work, Technology Networks spoke to CEO Prof. Andrea Pfeifer.
Immunotherapy is the prevention or treatment of disease with drugs that stimulate an immune response. Scientists are looking for a cure to Alzheimer’s disease that boosts our immune systems. Administering drugs to elicit an immune response works in a similar way to a vaccine and pharmaceutical companies are placing bets on immunotherapy to target Alzheimer’s disease.
The first infusion of an investigational drug that aims to delay or help to prevent the earliest memory loss due to Alzheimer’s disease took place in September at Butler Hospital in Providence, R.I., researchers announced.
“Risk factors point to an increased chance of developing the disease, and while some risk factors can’t be changed, there are others within your control, such as diet, exercise and sleep,” Boling says.
In our link for today, Boling breaks down five risk factors that people can look out for to reduce the risk of dementia.
Scientists have found associations between fungi living in the gut and mild cognitive impairment, which can lead to Alzheimer’s disease. They suggest that a ketogenic diet could help prevent the disease by creating a more healthful balance of microorganisms in the gut.
Flu and pneumonia vaccines were associated with a lower risk of developing Alzheimer’s disease among thousands of adults over age 60, according to two new studies presented Monday at the Alzheimer’s Association International Conference.
Although there’s still no cure, researchers are continuing to develop a better understanding of what increases a person’s risk of developing Alzheimer’s disease. A recent study that looked at 396 studies has even been able to identify ten risk factors that are shown to increase the likelihood of developing the disease.
Current research shows that genetics, high blood pressure, and smoking are all risk factors for developing dementia. But a lot of people don’t realise that there is also a relationship between mental ill-health and higher dementia risk too. Studies have shown that depression, anxiety, and post traumatic stress disorder are all linked to a higher risk of developing dementia in older age. Our recent study builds on this research by examining whether a style of thinking that is common to these mental health conditions is associated with indicators of Alzheimer’s disease, the most common type of dementia.
This June, during Alzheimer’s & Brain Awareness Month, join the Alzheimer’s Association to help raise awareness of this devastating disease. You can start by learning and sharing 10 Ways to Love your Brain.
Nearly six million people in the United States, including 76,000 Coloradans, are living with Alzheimer’s disease. The sixth-leading cause of death and the only leading disease without a prevention, treatment or cure, Alzheimer’s kills more Americans every year than breast cancer and prostate cancer combined.
When possible, combine these habits to achieve maximum benefit for the brain and body:
Effective measures include exercising regularly, engaging in “brain games” (including crossword puzzles, Sudoku or computer-based games), eating a heart-healthy Mediterranean diet, controlling high blood pressure and diabetes, and getting plenty of sleep.
A new study published in the journal Neurology in January 2020 concludes that increasing the intake of plant flavonols steeply reduces the risk of Alzheimer’s dementia (AD) by up to a half. In other words, AD could be prevented in many people simply by regularly eating and drinking more foods containing these compounds such as tea, oranges and broccoli.
The good folks over at Marketwatch give us a good overview of what we can do. Here is a part of what they say:
The research on cognitive health and disease has homed in on seven pillars for living a brain-healthy lifestyle, which may in combination, slash your risk for brain-degenerative diseases.
Just keep in mind, however, that even if you performed all these pillars perfectly, it doesn’t mean you won’t get Alzheimer’s disease. Other factors, such as genetics, additional medical conditions that affect the brain and accidents, can’t always be controlled.
For this to hit the market: There are two drugs that have been developed by Salk Institute researchers to successfully treat Alzheimer’s in mice—and now, they have found that the very same drug compounds can also slow the aging process in the brains of healthy older mice.
Researchers have now found that slower loss of cognitive skills in people with AD correlates with higher levels of a protein that helps immune cells clear plaque-like cellular debris from the brain . The efficiency of this clean-up process in the brain can be measured via fragments of the protein that shed into the cerebrospinal fluid (CSF). This suggests that the protein, called TREM2, and the immune system as a whole, may be promising targets to help fight Alzheimer’s disease.