A brief digital cognitive test improves Alzheimer’s disease detection

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BioCog is a brief, self-administered digital test battery that helps to accurately detect cognitive impairment in primary care patients undergoing evaluation for a possible neurodegenerative disease. When combined with blood biomarker tests, the digital test outperformed current standard-of-care assessments of Alzheimer’s disease, supporting a more precise, efficient and timely diagnosis.

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Lithium levels tied to Alzheimer’s disease and dementia

Alzheimer; News from the web:

Levels of lithium were significantly reduced in the prefrontal cortex of people with mild cognitive impairment and Alzheimer’s disease (AD).

In a mouse model of AD, a low-dose lithium salt in the diet reversed memory loss and prevented cognitive decline in aging mice.

While more study is needed, lithium replacement could be a potential approach to prevent and treat AD.

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Rather Than Driving, Hop on a Bike

Alzheimer; News from the web:

Middle-aged men and women who opted to cycle or walk had a lower risk of developing dementia years later than their peers who rode in a car or took a bus, according to a new report.

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Drugs for Alzheimer’s disease

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There is no cure for Alzheimer’s disease, but medication can help manage the condition. Currently, the main drugs used to treat Alzheimer’s are what’s known as symptomatic therapies, meaning they ease symptoms but don’t address the cause of the disease. These include cholinesterase inhibitors and memantine. A more recent entry into the field, lecanemab, may help slow the progression of the disease. Here’s a look at how these medications work.

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Controlling This One Molecule Could Halt Alzheimer’s in Its Tracks

Alzheimer; News from the web:

A groundbreaking study suggests that the immune molecule STING may play a critical role in Alzheimer’s and other neurodegenerative diseases by exacerbating brain inflammation and damage. Blocking STING in lab models protected against cognitive decline, opening a promising new path for therapeutic development.

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Exercise targets specific brain cells to protect against Alzheimer’s

Alzheimer; News from the web:

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer’s disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise. These findings, which were validated in samples from people, shed light on the connection between exercise and brain health and point to future drug targets. Results are published in Nature Neuroscience. 

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