Category Archives: Drugs

Lithium’s Surprising Effect on Alzheimer’s

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Scientists have identified new ways lithium chloride may interact with Alzheimer’s disease mechanisms at the cellular level.

A new study from the University of Eastern Finland (UEF) suggests lithium chloride may influence several cellular processes linked to Alzheimer’s disease.

Alzheimer’s disease (AD) is the most common type of dementia. One of its key features is the abnormal phosphorylation and buildup of Tau proteins inside brain cells, along with the accumulation of β-amyloid (Aβ) plaques.

Researchers have previously used lithium salts, especially lithium chloride and lithium carbonate, in cell and animal models of AD to reduce Tau hyperphosphorylation and aggregation. However, human clinical trials have produced inconsistent results, with some studies showing little or no improvement in cognitive function.

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FDA Approves First Non-Antipsychotic Drug to Treat Agitation Associated with Dementia

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The U.S. Food and Drug Administration today approved an expanded use for Auvelity (dextromethorphan hydrobromide and bupropion hydrochloride) extended-release tablets to treat agitation associated with dementia due to Alzheimer’s disease in adults. The drug is the first FDA-approved treatment for this condition that is not an antipsychotic. FDA initially approved Auvelity in 2022 to treat major depressive disorder in adults.

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Much-Hyped Alzheimer’s Drugs Show No Meaningful Benefit, Major Review Finds

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Drugs once hailed as a breakthrough in the fight against Alzheimer’s disease do not meaningfully help patients, a major review found Thursday, however some experts criticized the research.

The review by the Cochrane organization – which is considered the gold standard for analyzing existing evidence – looked at drugs that target a plaque called amyloids, which builds up in the brains of Alzheimer’s patients.

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Drugs for Alzheimer’s disease

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Alzheimer; News from the web:

There is no cure for Alzheimer’s disease, but medication can help manage the condition. Currently, the main drugs used to treat Alzheimer’s are what’s known as symptomatic therapies, meaning they ease symptoms but don’t address the cause of the disease. These include cholinesterase inhibitors and memantine. A more recent entry into the field, lecanemab, may help slow the progression of the disease. Here’s a look at how these medications work.

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