Alzheimer; News from the web:
The NIHR University College London Hospitals (UCLH) Clinical Research Facility in the UK has initiated a clinical trial, DESPIAD, to assess a new treatment called miridesap for Alzheimer’s disease.
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Alzheimer; News from the web:
Good explanation of why it is so difficult to develop an Alzheimer’s drug and which one is leading the pack.
Expect next year some results about these hopeful developments.
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Alzheimer; News from the web:
Will take another decade to come and the development seems to cost about $10B
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Alzheimer; News from the web:
A new study from The University of Texas Medical Branch at Galveston has provided researchers important insights about an enzyme within the brain that plays a critical role in Alzheimer’s.
The UTMB researchers found that blocking the enzyme helped prevent memory loss in mice.
The enzyme is a promising target for developing medications to prevent cognitive decline. The study was recently published in Alzheimer’s and Dementia: Translational Research and Clinical Interventions.
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Alzheimer; News from the web:
This makes sense, if Alzheimer’s is most prevalent in older people, one way to slow down the disease is to slow down your aging. Read up on this novel approach.
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Alzheimer; News from the web:
Interesting, the video on the page in the link for today highlights life style changes while the words on the site talk about a new compound that has been found that could prevent Alzheimer’s. Both are interesting to read/watch.
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Alzheimer; News from the web:
It has been known that people can be disoriented after general anesthesia but now a study found that propofol (a very common drug to use) also disrupts presynaptic mechanisms, probably affecting communication between neurons across the entire brain in a systematic way that differs from just being asleep. In this way it is very different than a sleeping pill
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Alzheimer; News from the web:
In a new study, a Salk team found that J147 binds to a protein called ATP synthase, which is responsible for producing a common cellular “energy currency” known as ATP. This protein is known to control aging in worms and flies, and the researchers found that by binding to it the drug was able to prevent age-related damage to the brain.
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Alzheimer; News from the web:
Good news, the drug industry is not giving up on Alzheimer’s drugs despite lack of results so far. Would it be greed or their passion to help? Who knows but it is good news.
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Alzheimer; News from the web:
Jalisco gene mutation causes early-onset Alzheimer’s. There is only 1 percent of Alzheimer’s patients who have genetic mutations known to cause the disease.
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Alzheimer; News from the web:
Scientists report that a novel small-molecule drug, which works by stopping toxic ion flow in the brain that is known to trigger neuronal apoptosis, can restore brain function and memory in a mouse model of Alzheimer’s disease (AD). The team believes the drug could be used to treat AD and other neurodegenerative diseases such as Parkinson’s and amyotropic lateral sclerosis (ALS).
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Alzheimer; News from the web:
You would think that all would be working cooperatively towards a solution for Alzheimer’s but this is not the case. The ridiculous costs and time that it takes to run effective tests lead to a short time to recoup your research costs when you would find a workable solution. Researchers can not make a good case that this is a wise investment for Pharmaceutical companies.
So something is really wrong here and the government should look into this.
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Alzheimer; News from the web:
Buildups of “clumpy” proteins in the brain are well-known hallmarks of Alzheimer’s, but not everyone who has them goes on to develop this neurodegenerative disease. Why is that? New research investigates.
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Alzheimer; News from the web:
Dr. Debbie Toiber, of the BGU Department of Life Sciences, and her team discovered that a specific protein — Sirtuin-6 (SIRT6) — is severely reduced in the brains of Alzheimer’s patients. SIRT6 is critical to the repair of DNA, the deterioration of which “is the beginning of the chain that ends in neurodegenerative diseases in seniors,” she explains.
The blood-brain barrier prevents us from simply being able to inject the protein into the brain to replenish its supply. Dr. Toiber is currently working on finding a way to increase the expression of the protein into the brain.
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Alzheimer; News from the web:
Ionis and Biogen are bringing to bear the Ionis drug technology called antisense, which targets diseases processes at the genetic level. It blocks or modifies production of proteins involved in disease.
The Phase 1/2a study of the Alzheimer’s drug, IONIS-MAPTRx, seeks evidence of safety and signs of activity. It’s to be given in 44 patients with mild Alzheimer’s over three months.The drug targets microtubule-associated tau protein, also called MATP, or tau, an abnormal protein associated with Alzheimer’s.
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Alzheimer; News from the web:
As a first step, a team is testing whether it’s possible to stop or slow tau-driven neuron loss and inflammation by lowering ApoE in the early life of laboratory rodents. This scheme mimics a human scenario better than the recent study, which analyzed mice that express or lack APOE from birth. “The implication here, with the recent tau findings, is that you’d really block the neurodegeneration that leads to cognitive decline,” Holtzman says.
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Alzheimer; News from the web:
Research on mice suggests disease does not wipe memories, but makes them harder to access
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Alzheimer; News from the web:
Nearly three dozen new Alzheimer’s drugs may reach the market in the next five years, researchers say.
That includes 27 drugs in phase 3 clinical trials, which are later in the drug review process. It also includes eight drugs in phase 2 clinical trials, according to an analysis by ResearchersAgainstAlzheimer’s (RA2) investigators, an UsAgainstAlzheimer’s network.
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Alzheimer; News from the web:
Drugs used to treat acid reflux and ulcers don’t appear to boost the risk of dementia, as has been previously suspected, new research suggests.
The study focused on widely used proton pump inhibitors (PPIs) drugs — medicines such as Prevacid, Prilosec and Nexium. Previous studies have suggested the drugs may increase the risk of dementia and Alzheimer’s disease in people aged 75 and older.
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Alzheimer; News from the web:
An InSysBio scientific group led by Tatiana Karelina has developed a quantitative system pharmacology model of Alzheimer’s disease. The first part has been published in CPT Pharmacometrics & Systems Pharmacology, and shows how to design initial phases of clinical trials of new drugs and to interpret the data.
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Alzheimer; News from the web:
This could increase the pace of finding a cure. Researchers are looking at how HIV got brought mostly under control:
The Alzheimer’s Association has partnered with the Alzheimer’s Drug Discovery Foundation (ADDF) to challenge the research community to propose promising drug combinations to find more-effective treatments.
The joint effort, known as the Alzheimer’s Combination Therapy Opportunities (ACTO) grant initiative, will provide $2 million this year for testing approaches that simultaneously target two or more processes believed to underlie, exacerbate, or occur in the disease.
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Alzheimer; News from the web:
Researchers urge FDA to lower the bar — a little — on Alzheimer’s drug approvals
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Alzheimer; News from the web:
Australian researchers say they have made a promising step in the future treatment of Alzheimer’s disease after discovering ultrasound can effectively and safely deliver drugs to the damaged brain.
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Alzheimer; News from the web:
Makers of an Alzheimer’s drug are hoping it will become the first new treatment for the disease available to sufferers for over a decade if trials conclude successfully later this year.
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Alzheimer; News from the web:
According to The Scientific American:
“A Rare Success against Alzheimer’s,” by researchers Miia Kivipelto and Krister Håkansson, the future may not be quite so grim. In fact, studies show that reducing the risk of Alzheimer’s and other forms of dementia may include factors as simple as “good diet, exercise, an active social life and the achievement of higher educational levels.”
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Alzheimer; News from the web:
Drug company Merck said Tuesday it’s halting the late-stage trial of its promising Alzheimer’s drug verubecestat, after an independent study found that it had “virtually no chance” of working.
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Alzheimer; News from the web:
A new study sees a role for a Herpes type 1 medicine and in the next year the scientists hope to prove that the drug that fights the Herpes virus will also eliminate Alzheimer’s. We are hopeful!
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Alzheimer; News from the web:
Researchers at the Cleveland Clinic have presented findings on an experimental drug they say could offer new hope. The drug, called NTRX-07, was used in animal studies and appears to have diminished some of the effects that Alzheimer’s has on the brain.
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