Will we ever find a cure?

Alzheimer; News from the web:

The New York Times has a great article today, read it in our link below.

“The field is desperate, and we all want something to work,” said Dr. Reisa Sperling, director of the Center for Alzheimer Research and Treatment at Brigham and Women’s Hospital in Boston.

Read all about it HERE

(our blog will be on a short break to celebrate the US Thanksgiving, back on Monday)

New research promising for prevention of cognitive decline

Alzheimer; News from the web:

A new study from The University of Texas Medical Branch at Galveston has provided researchers important insights about an enzyme within the brain that plays a critical role in Alzheimer’s.

The UTMB researchers found that blocking the enzyme helped prevent memory loss in mice.

The enzyme is a promising target for developing medications to prevent cognitive decline. The study was recently published in Alzheimer’s and Dementia: Translational Research and Clinical Interventions.

Read all about it HERE

Brain muddled after surgery? Now we know why.

Alzheimer; News from the web:

It has been known that people can be disoriented after general anesthesia but now a study found that propofol (a very common drug to use) also disrupts presynaptic mechanisms, probably affecting communication between neurons across the entire brain in a systematic way that differs from just being asleep. In this way it is very different than a sleeping pill

Read all about it HERE

Another promising Alzheimer’s drug

Alzheimer; News from the web:

In a new study, a Salk team found that J147 binds to a protein called ATP synthase, which is responsible for producing a common cellular “energy currency” known as ATP. This protein is known to control aging in worms and flies, and the researchers found that by binding to it the drug was able to prevent age-related damage to the brain.

Read all about it HERE

I want to believe this

Alzheimer; News from the web:

Novel Drug Shows Promising Results in Alzheimer’s Model

  • Scientists report that a novel small-molecule drug, which works by stopping toxic ion flow in the brain that is known to trigger neuronal apoptosis, can restore brain function and memory in a mouse model of Alzheimer’s disease (AD). The team believes the drug could be used to treat AD and other neurodegenerative diseases such as Parkinson’s and amyotropic lateral sclerosis (ALS).

Read all about it HERE

Patent law an obstacle for Alzheimer’s solutions

Alzheimer; News from the web:

You would think that all would be working cooperatively towards a solution for Alzheimer’s but this is not the case. The ridiculous costs and time that it takes to run effective tests lead to a short time to recoup your research costs when you would find a workable solution. Researchers can not make a good case that this is a wise investment for Pharmaceutical companies.

So something is really wrong here and the government should look into this.

Read all about it HERE

Israeli researchers may have found a trigger!

Alzheimer; News from the web:

Dr. Debbie Toiber, of the BGU Department of Life Sciences, and her team discovered that a specific protein — Sirtuin-6 (SIRT6) — is severely reduced in the brains of Alzheimer’s patients. SIRT6 is critical to the repair of DNA, the deterioration of which “is the beginning of the chain that ends in neurodegenerative diseases in seniors,” she explains.

The blood-brain barrier prevents us from simply being able to inject the protein into the brain to replenish its supply. Dr. Toiber is currently working on finding a way to increase the expression of the protein into the brain.

Read all about it HERE

Four trials go to human phase!

Alzheimer; News from the web:

Ionis and Biogen are bringing to bear the Ionis drug technology called antisense, which targets diseases processes at the genetic level. It blocks or modifies production of proteins involved in disease.

The Phase 1/2a study of the Alzheimer’s drug, IONIS-MAPTRx, seeks evidence of safety and signs of activity. It’s to be given in 44 patients with mild Alzheimer’s over three months.The drug targets microtubule-associated tau protein, also called MATP, or tau, an abnormal protein associated with Alzheimer’s.

Read all about it HERE

The Alzheimer’s gene as a target!

Alzheimer; News from the web:

As a first step, a team is testing whether it’s possible to stop or slow tau-driven neuron loss and inflammation by lowering ApoE in the early life of laboratory rodents. This scheme mimics a human scenario better than the recent study, which analyzed mice that express or lack APOE from birth. “The implication here, with the recent tau findings, is that you’d really block the neurodegeneration that leads to cognitive decline,” Holtzman says.

Read all about it HERE

Alzheimer; News from the web:

Nearly three dozen new Alzheimer’s drugs may reach the market in the next five years, researchers say.

That includes 27 drugs in phase 3 clinical trials, which are later in the drug review process. It also includes eight drugs in phase 2 clinical trials, according to an analysis by ResearchersAgainstAlzheimer’s (RA2) investigators, an UsAgainstAlzheimer’s network.

Read all about it HERE

Heartburn meds are not a problem for Alzheimer’s after all

Alzheimer; News from the web:

Drugs used to treat acid reflux and ulcers don’t appear to boost the risk of dementia, as has been previously suspected, new research suggests.

The study focused on widely used proton pump inhibitors (PPIs) drugs — medicines such as Prevacid, Prilosec and Nexium. Previous studies have suggested the drugs may increase the risk of dementia and Alzheimer’s disease in people aged 75 and older.

Read all about it HERE

Accelerating drug discovery for Alzheimer’s

Alzheimer; News from the web:

An InSysBio scientific group led by Tatiana Karelina has developed a quantitative system pharmacology model of Alzheimer’s disease. The first part has been published in CPT Pharmacometrics & Systems Pharmacology, and shows how to design initial phases of clinical trials of new drugs and to interpret the data.

Read all about it HERE

Maybe we need a mix of drugs to fight Alzheimer’s

Alzheimer; News from the web:

This could increase the pace of finding a cure. Researchers are looking at how HIV got brought mostly under control:

The Alzheimer’s Association has partnered with the Alzheimer’s Drug Discovery Foundation (ADDF) to challenge the research community to propose promising drug combinations to find more-effective treatments.

The joint effort, known as the Alzheimer’s Combination Therapy Opportunities (ACTO) grant initiative, will provide $2 million this year for testing approaches that simultaneously target two or more processes believed to underlie, exacerbate, or occur in the disease.

Read all about it HERE

The future may not be so grim

Alzheimer; News from the web:

According to The Scientific American:

A Rare Success against Alzheimer’s,” by researchers Miia Kivipelto and Krister Håkansson, the future may not be quite so grim. In fact, studies show that reducing the risk of Alzheimer’s and other forms of dementia may include factors as simple as “good diet, exercise, an active social life and the achievement of higher educational levels.”

Read all about it HERE