Alzheimer; News from the web:
Researchers have found that nilvadipine, a drug that doctors regularly use to treat hypertension, may help people with Alzheimer’s disease by increasing blood flow to the brain.
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Alzheimer; News from the web:
A cure for Alzheimer’s Disease does not exist just yet, but researchers at the University of New Mexico (UNM) are one step closer to finding one.
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Alzheimer; News from the web:
Treatment with blood pressure medication can improve blood flow to a key brain region in people with Alzheimer’s disease, a small clinical trial has found.
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Alzheimer; News from the web:
Alzheimer’s drugs cost seven times more than cancer drugs to develop
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Alzheimer; News from the web:
There are roughly 326 active, recruiting or enrolling by invitation clinical trials on the elusive disease, per clinicaltrial.gov. The U.S. last year dramatically stepped up funding for Alzheimer’s disease research, from $400 million a year to over $2 billion annually, although the Alzheimer’s Association says more is needed.
The biggest problem: Scientists still don’t know the cause of Alzheimer’s.
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Alzheimer; News from the web:
Here is a new drug that seemed effective for mice and now has been found safe for humans, so the next step it to test it on patients with Alzheimer’s. Exciting times
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Alzheimer; News from the web:
The companies developing aducanumab, Biogen and its partner Eisai, announced that they halted two late-stage trials of the experimental drug after an independent group’s analysis showed that the trials were unlikely to “meet their primary endpoint.”
The Cambridge, Massachusetts-based biotech giant joins a long list of companies in the last decade that have failed to find a treatment for Alzheimer’s.
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Alzheimer; News from the web:
Check out the project in the link for today. The claim is a novel process to find a way to immunize against Alzheimer’s disease. Not sure how this low budget will win from all the billions already spent by the large pharmaceutical companies but see for yourself.
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Alzheimer; News from the web:
Yes now we are at the stage that doctors are seriously think they may have found a way to prevent Alzheimer’s to happen. In May, doctors in New York will start testing a novel gene therapy
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Alzheimer; News from the web:
A new drug shows promising results: Early results indicate that the drug could reverse natural, age-related cognitive decline. Researchers also believe that it might help patients whose memories are impaired because of conditions such as depression, schizophrenia and Alzheimer’s disease.
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Alzheimer; News from the web:
Despite Roche’s recent trial failure for crenezumab, the ProMIS team remain confident a disease-modifying treatment will be found in the next decade.
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Alzheimer; News from the web:
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Alzheimer; News from the web:
The New York Times has a great article today, read it in our link below.
“The field is desperate, and we all want something to work,” said Dr. Reisa Sperling, director of the Center for Alzheimer Research and Treatment at Brigham and Women’s Hospital in Boston.
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(our blog will be on a short break to celebrate the US Thanksgiving, back on Monday)
Alzheimer; News from the web:
The NIHR University College London Hospitals (UCLH) Clinical Research Facility in the UK has initiated a clinical trial, DESPIAD, to assess a new treatment called miridesap for Alzheimer’s disease.
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Alzheimer; News from the web:
Good explanation of why it is so difficult to develop an Alzheimer’s drug and which one is leading the pack.
Expect next year some results about these hopeful developments.
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Alzheimer; News from the web:
Will take another decade to come and the development seems to cost about $10B
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Alzheimer; News from the web:
A new study from The University of Texas Medical Branch at Galveston has provided researchers important insights about an enzyme within the brain that plays a critical role in Alzheimer’s.
The UTMB researchers found that blocking the enzyme helped prevent memory loss in mice.
The enzyme is a promising target for developing medications to prevent cognitive decline. The study was recently published in Alzheimer’s and Dementia: Translational Research and Clinical Interventions.
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Alzheimer; News from the web:
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Alzheimer; News from the web:
This makes sense, if Alzheimer’s is most prevalent in older people, one way to slow down the disease is to slow down your aging. Read up on this novel approach.
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Alzheimer; News from the web:
Interesting, the video on the page in the link for today highlights life style changes while the words on the site talk about a new compound that has been found that could prevent Alzheimer’s. Both are interesting to read/watch.
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Alzheimer; News from the web:
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Alzheimer; News from the web:
It has been known that people can be disoriented after general anesthesia but now a study found that propofol (a very common drug to use) also disrupts presynaptic mechanisms, probably affecting communication between neurons across the entire brain in a systematic way that differs from just being asleep. In this way it is very different than a sleeping pill
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Alzheimer; News from the web:
In a new study, a Salk team found that J147 binds to a protein called ATP synthase, which is responsible for producing a common cellular “energy currency” known as ATP. This protein is known to control aging in worms and flies, and the researchers found that by binding to it the drug was able to prevent age-related damage to the brain.
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Alzheimer; News from the web:
Good news, the drug industry is not giving up on Alzheimer’s drugs despite lack of results so far. Would it be greed or their passion to help? Who knows but it is good news.
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Alzheimer; News from the web:
Jalisco gene mutation causes early-onset Alzheimer’s. There is only 1 percent of Alzheimer’s patients who have genetic mutations known to cause the disease.
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Alzheimer; News from the web:
Scientists report that a novel small-molecule drug, which works by stopping toxic ion flow in the brain that is known to trigger neuronal apoptosis, can restore brain function and memory in a mouse model of Alzheimer’s disease (AD). The team believes the drug could be used to treat AD and other neurodegenerative diseases such as Parkinson’s and amyotropic lateral sclerosis (ALS).
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Alzheimer; News from the web:
You would think that all would be working cooperatively towards a solution for Alzheimer’s but this is not the case. The ridiculous costs and time that it takes to run effective tests lead to a short time to recoup your research costs when you would find a workable solution. Researchers can not make a good case that this is a wise investment for Pharmaceutical companies.
So something is really wrong here and the government should look into this.
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Alzheimer; News from the web:
Buildups of “clumpy” proteins in the brain are well-known hallmarks of Alzheimer’s, but not everyone who has them goes on to develop this neurodegenerative disease. Why is that? New research investigates.
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Alzheimer; News from the web:
Dr. Debbie Toiber, of the BGU Department of Life Sciences, and her team discovered that a specific protein — Sirtuin-6 (SIRT6) — is severely reduced in the brains of Alzheimer’s patients. SIRT6 is critical to the repair of DNA, the deterioration of which “is the beginning of the chain that ends in neurodegenerative diseases in seniors,” she explains.
The blood-brain barrier prevents us from simply being able to inject the protein into the brain to replenish its supply. Dr. Toiber is currently working on finding a way to increase the expression of the protein into the brain.
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Alzheimer; News from the web:
Ionis and Biogen are bringing to bear the Ionis drug technology called antisense, which targets diseases processes at the genetic level. It blocks or modifies production of proteins involved in disease.
The Phase 1/2a study of the Alzheimer’s drug, IONIS-MAPTRx, seeks evidence of safety and signs of activity. It’s to be given in 44 patients with mild Alzheimer’s over three months.The drug targets microtubule-associated tau protein, also called MATP, or tau, an abnormal protein associated with Alzheimer’s.
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