I want to believe this

Alzheimer; News from the web:

Novel Drug Shows Promising Results in Alzheimer’s Model

  • Scientists report that a novel small-molecule drug, which works by stopping toxic ion flow in the brain that is known to trigger neuronal apoptosis, can restore brain function and memory in a mouse model of Alzheimer’s disease (AD). The team believes the drug could be used to treat AD and other neurodegenerative diseases such as Parkinson’s and amyotropic lateral sclerosis (ALS).

Read all about it HERE

Patent law an obstacle for Alzheimer’s solutions

Alzheimer; News from the web:

You would think that all would be working cooperatively towards a solution for Alzheimer’s but this is not the case. The ridiculous costs and time that it takes to run effective tests lead to a short time to recoup your research costs when you would find a workable solution. Researchers can not make a good case that this is a wise investment for Pharmaceutical companies.

So something is really wrong here and the government should look into this.

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Israeli researchers may have found a trigger!

Alzheimer; News from the web:

Dr. Debbie Toiber, of the BGU Department of Life Sciences, and her team discovered that a specific protein — Sirtuin-6 (SIRT6) — is severely reduced in the brains of Alzheimer’s patients. SIRT6 is critical to the repair of DNA, the deterioration of which “is the beginning of the chain that ends in neurodegenerative diseases in seniors,” she explains.

The blood-brain barrier prevents us from simply being able to inject the protein into the brain to replenish its supply. Dr. Toiber is currently working on finding a way to increase the expression of the protein into the brain.

Read all about it HERE

Four trials go to human phase!

Alzheimer; News from the web:

Ionis and Biogen are bringing to bear the Ionis drug technology called antisense, which targets diseases processes at the genetic level. It blocks or modifies production of proteins involved in disease.

The Phase 1/2a study of the Alzheimer’s drug, IONIS-MAPTRx, seeks evidence of safety and signs of activity. It’s to be given in 44 patients with mild Alzheimer’s over three months.The drug targets microtubule-associated tau protein, also called MATP, or tau, an abnormal protein associated with Alzheimer’s.

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The Alzheimer’s gene as a target!

Alzheimer; News from the web:

As a first step, a team is testing whether it’s possible to stop or slow tau-driven neuron loss and inflammation by lowering ApoE in the early life of laboratory rodents. This scheme mimics a human scenario better than the recent study, which analyzed mice that express or lack APOE from birth. “The implication here, with the recent tau findings, is that you’d really block the neurodegeneration that leads to cognitive decline,” Holtzman says.

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Alzheimer; News from the web:

Nearly three dozen new Alzheimer’s drugs may reach the market in the next five years, researchers say.

That includes 27 drugs in phase 3 clinical trials, which are later in the drug review process. It also includes eight drugs in phase 2 clinical trials, according to an analysis by ResearchersAgainstAlzheimer’s (RA2) investigators, an UsAgainstAlzheimer’s network.

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Heartburn meds are not a problem for Alzheimer’s after all

Alzheimer; News from the web:

Drugs used to treat acid reflux and ulcers don’t appear to boost the risk of dementia, as has been previously suspected, new research suggests.

The study focused on widely used proton pump inhibitors (PPIs) drugs — medicines such as Prevacid, Prilosec and Nexium. Previous studies have suggested the drugs may increase the risk of dementia and Alzheimer’s disease in people aged 75 and older.

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Accelerating drug discovery for Alzheimer’s

Alzheimer; News from the web:

An InSysBio scientific group led by Tatiana Karelina has developed a quantitative system pharmacology model of Alzheimer’s disease. The first part has been published in CPT Pharmacometrics & Systems Pharmacology, and shows how to design initial phases of clinical trials of new drugs and to interpret the data.

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Maybe we need a mix of drugs to fight Alzheimer’s

Alzheimer; News from the web:

This could increase the pace of finding a cure. Researchers are looking at how HIV got brought mostly under control:

The Alzheimer’s Association has partnered with the Alzheimer’s Drug Discovery Foundation (ADDF) to challenge the research community to propose promising drug combinations to find more-effective treatments.

The joint effort, known as the Alzheimer’s Combination Therapy Opportunities (ACTO) grant initiative, will provide $2 million this year for testing approaches that simultaneously target two or more processes believed to underlie, exacerbate, or occur in the disease.

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The future may not be so grim

Alzheimer; News from the web:

According to The Scientific American:

A Rare Success against Alzheimer’s,” by researchers Miia Kivipelto and Krister Håkansson, the future may not be quite so grim. In fact, studies show that reducing the risk of Alzheimer’s and other forms of dementia may include factors as simple as “good diet, exercise, an active social life and the achievement of higher educational levels.”

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Marijuana to cure Alzheimer’s?

Alzheimer; News from the web:

According to a new study published in the Aging and Mechanisms of Disease journal on Friday [July 1], the active compound tetrahydrocannabinol also known as THC has the potential to cure Alzheimer’s Disease.

The study concluded that the compound in conjunction with others found in marijuana can help with the removal of toxic proteins, amyloid beta, that contribute to the disease.

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Researching Alzheimer’s with your husband

Alzheimer; News from the web:

Dorene Rentz, one of 
the local neuropsychologists behind a pioneering Alzheimer’s study, spends her days searching for 
answers in the mysterious plaques that invade the brains of those suffering from the incurable disease.

And Rentz’s search will take on a new sense of urgency in the coming months, as the study gains a key participant: her husband.

Read all about it HERE

Alzheimer’s breakthrough?

Alzheimer; News from the web:

Could it be true this time?

Researchers in the U.K. have found that blocking a receptor in the brain that regulates immune cells could “protect against the memory and behavior changes seen in the progression of Alzheimer’s disease.”

According to a news release from the University of Southampton, the research by scientists looking into how Alzheimer’s progresses in the human brain has added to evidence that “inflammation in the brain can in fact drive the development of the disease.”

The study’s findings, published on Friday in the journal Brain, point to the disease potentially being halted if inflammation in the brain is reduced, with hopes of an effective new treatment being developed as a result.

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More than one Alzheimer’s?

Alzheimer; News from the web:

A study done in August suggested that there may be more sorts of Alzheimer’s disease; inflammatory, noninflammatory and cortical.

They would each need different treatment and it may be the reason why lots of drug have failed so far.

Read all about it HERE