Category Archives: Research

Millions take omega-3 fish oil for brain health but a new study found no benefit

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A large clinical trial found that omega-3 fish oil supplements failed to improve memory or slow brain changes associated with Alzheimer’s disease.

Date:June 29, 2026Source:University of Southern California – Health SciencesSummary:Fish oil supplements successfully delivered omega-3s to the brain, but a two-year study found no meaningful benefits for memory, cognition, or Alzheimer’s-related brain changes. The results challenge the idea that fish oil pills can help prevent Alzheimer’s and shift attention toward overall diet and lifestyle instead.

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Scientists discover mechanism for brain cell death in Alzheimer’s disease

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For decades, scientists have known that toxic proteins build up in the brains of people living with Alzheimer’s disease and frontotemporal dementia (FTD), but exactly how this leads to the death of brain cells has remained unclear. Now, researchers at King’s College London and the UK Dementia Research Institute have uncovered a new mechanism in Alzheimer’s disease and FTD that could help explain why. Their findings offer fresh hope for treatments that may slow disease progression and preserve brain function. 

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Associations of stable psychological traits with multi-omic subtypes of Alzheimer’s dementia

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Psychological traits reflecting neuroticism, depressive symptoms, loneliness, and purpose in life are risk factors of AD dementia; however, the underlying biological mechanisms remain largely unknown. Using multi-omic data from the dorsolateral prefrontal cortex of 822 decedents in the Religious Orders Study and Rush Memory and Aging Project, we utilized a previously derived multi-omic brain molecular pseudotime representing molecular distance from no cognitive impairment (NCI) to AD dementia, and three distinct multi-omic brain molecular subtypes of AD dementia. 

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Age-Related Mutations in Brain Immune Cells Linked to Alzheimer’s Inflammation

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Researchers have uncovered evidence that age-related genetic mutations commonly associated with cancer and blood disorders may also contribute to the chronic brain inflammation characteristic of Alzheimer’s disease.

In a study published in Cell, investigators from the Icahn School of Medicine at Mount Sinai and Boston Children’s Hospital identified somatic mutations in brain immune cells from patients with Alzheimer’s disease. The findings suggest that genetic alterations acquired during aging may reshape the behavior of these cells, driving inflammatory processes linked to neurodegeneration.

The work introduces a potential new biological mechanism connecting aging, immune dysfunction, and Alzheimer’s disease, a condition that affects millions of people worldwide and remains one of the leading causes of dementia.

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Researchers Find Cancer-Linked Mutations in Alzheimer’s Brain Cells

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The microglia are small immune cells that patrol the brain looking for damage and invaders. When they encounter damage, infections, or protein plaques, they retract their many arms and turn into a rounded blob that eats invaders and toxins, and alerts other immune cells. 

In Alzheimer’s, these protective cells go haywire, leading to excess inflammation which might help drive the disease. 

Previous research suggested an unexpected explanation for the phenomenon: A cancer-driving genetic mutation in the microglia. August Yue Huang, a researcher at Boston Children’s Hospital and Harvard Medical School, wanted to know whether the microglia of people with Alzheimer’s harbored more of these mutations than in healthy aging adults. 

His recent study in the journal Cell showed that microglia harbor multiple cancer-driving mutations, shifting them into a pro-inflammatory state that may contribute to Alzheimer’s. 

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