Finally a cure?

Alzheimer; News from the web:

A drug called aducanumab could become the first approved treatment designed to alter the course of Alzheimer’s disease rather than relieve symptoms.

But it’s unclear whether the Food and Drug Administration will approve the drug because of persistent questions about its effectiveness.

Read all about it HERE

‘Rejuvenating’ the Alzheimer’s brain

Alzheimer; News from the web:

Alzheimer’s disease is the main cause of dementia and current therapeutic strategies cannot prevent, slow down or cure the pathology. The disease is characterized by memory loss, caused by the degeneration and death of neuronal cells in several regions of the brain, including the hippocampus. Researchers have identified a small molecule that can be used to rejuvenate the brain and counteract the memory loss.

Read all about it HERE

Air quality may impact Alzheimer’s

Alzheimer; News from the web:

Researchers at the University of California, Davis, have found a link between traffic-related air pollution and an increased risk for age-related dementia, including Alzheimer’s disease. Their study, based on rodent models, corroborates previous epidemiological evidence showing this association.

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AI can help Alzheimer’s

Alzheimer; News from the web:

Have you ever wondered how Netflix knows the perfect show to recommend next? Or how Facebook suggests just the person you were looking to follow? 

Researchers have found the power of those predicting algorithms can also “predict” the biological language of cancer and neurodegenerative diseases like Alzheimer’s – which could help change completely what researchers know about treating and preventing such diseases.

Read all about it HERE

13 Alzheimer’s gene variants found

Alzheimer; News from the web:

Researchers have identified 13 variants of genes connected to Alzheimer’s disease that are new to scientists. In a study published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, the researchers report how they sequenced whole genomes of people in more than 600 families with individuals who have been diagnosed with Alzheimer’s and searched for rare versions of genes.

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Gender and Alzheimer’s

Alzheimer; News from the web:

Mounting evidence suggests that a distinction in the chemistry or structure of women’s brains may be a factor — a distinction that may lead to a sex-based difference in the appearance and aggregation of tau and beta-amyloid proteins, key biomarkers of Alzheimer’s. In a study published this month in Brainresearchers at Lund University in Sweden have found evidence that the protein tau accumulates at a higher rate in women.

Read all about it HERE

A new approach to treat Alzheimer’s disease

Alzheimer; News from the web:

A new approach to treat Alzheimer’s disease, potentially targeting the root cause of memory decline

The ACT-AD and LIFT-AD trials are evaluating if a new investigational drug is safe and effective in improving symptoms of mild to moderate Alzheimer’s disease.

The investigational drug of the ACT-AD and LIFT-AD trials is designed to:

  • Boost a repair and regenerative pathway for brain cells
  • Promote brain health and function

There may be a trial near you check it out

Read all about it HERE

Not 1 but 3 Alzheimer’s?

Alzheimer; News from the web:

What if we think of Alzheimer’s not as one disease, but three separate ones, with overlapping symptoms? Researchers behind a new study say Alzheimer’s encapsulates three distinct molecular conditions, and that a better understanding of each could be a lifeline for failed Alzheimer’s treatment efforts and future research.

Read all about it HERE

For Alzheimer’s Patients, Racial Disparities Threaten Detection and Treatment

Alzheimer; News from the web:

Black people are about twice as likely as White people to get the disease, and Latino residents are 1.5 times more likely to suffer from it than White people. Besides their higher risks, people of color face additional Alzheimer’s challenges: noted racial disparities in how the disease is detected and how research on it is done.

Read all about it HERE

Alzheimer’s impact on covid-19

Alzheimer; News from the web:

Our study provides a causal link between the Alzheimer’s disease risk factor ApoE4 and COVID-19 and explains why some (e.g., ApoE4 carriers) but not all COVID-19 patients exhibit neurological manifestations. Understanding how risk factors for neurodegenerative diseases impact COVID-19 susceptibility and severity will help us to better cope with COVID-19 and its potential long-term effects in different patient populations.”

Yanhong Shi, Ph.D., Director, Division of Stem Cell Biology, City of Hope and Study’s Co-Corresponding Author

Read all about it HERE

Living in a Noisy Neighborhood May Cause Alzheimer’s Disease, According to Recent Study

Alzheimer; News from the web:

Individuals who reside in louder regions are more at risk of developing Alzheimer’s, new report shows.

A sound-level spike of only 10 decibels raised the risk by 30 percent. That is the gap between breathing and whispering. It also culminated in 36 percent greater chances of moderate cognitive disability, including memory and reasoning ability, scientists said.

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Improving apathy in Alzheimer patients with brain stimulation

Alzheimer; News from the web:

Twenty Veterans with Alzheimer’s disease and apathy took part in a pilot study. Half received repetitive transcranial magnetic stimulation (rTMS), a type of brain stimulation. The others received sham stimulation, basically a placebo.

Through patient and caregiver interviews, the VA team documented “significantly greater improvement” in apathy levels in those who received brain stimulation compared with the control group. The positive effects continued up to three months.

Besides improvements in apathy, the researchers also noted “significantly greater improvement” in memory, attention, and cognition in the rTMS patients compared with the sham treatment group.

Read all about it HERE

Helping Alzheimer’s Patients Bring Back Memories

Alzheimer; News from the web:

The writer of the post in our link for today  developed an approach that allowed us to activate the neurons that store memory information, referred to as memory engrams, through optogenetics—that is, introducing a gene that is light sensitive into the memory engram cells of “Alzheimer’s” mice, then delivering blue light pulses to activate them—and measuring memory recall strength directly. To our surprise, we found comparable numbers of engram cells in normal healthy animals and Alzheimer’s animals, suggesting that the initial memory storage process is intact. Targeting the recall process in Alzheimer’s animals led to an improvement in their memory, which reached the performance level of normal animals.

Read all about it HERE

11 ways to prevent Alzheimer’s

Alzheimer; News from the web:

Great Article by Yahoo style where they not only give 11 ways to prevent Alzheimer’s but also refer to the appropriate research that has come up with this way to avoid Alzheimer’s.

In short: Get sleep, get moving, eat mediterranean, be social, don’t (almost) drink, loose weight, learn new things, wear helmet and belts, get balanced, manage blood pressure, quit smoking.

Don’t just read this summery, go for the full article and take some great actions today!

Read all about it HERE

A Vaccine for Alzheimer’s Disease?

Alzheimer; News from the web:

Swiss biopharma AC Immune has made targeting Alzheimer’s disease, the leading form of dementia, a top priority. The company’s numerous candidates and platforms target several different proteins and pathways thought to have a central role in Alzheimer’s pathology. 2020 has brought mixed news for AC Immune. In July, the company announced that their candidate tau vaccine, ACI-35.030, had shown “encouraging” safety data at a lower dose and was to be progressed to a higher-dose group. However, September brought the disappointing news that their anti-tau antibody, semorinemab, did not meet its primary efficacy endpoints in a Phase 2 trial. To discuss AC Immune’s work, Technology Networks spoke to CEO Prof. Andrea Pfeifer.

https://www.technologynetworks.com/

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FDA does not approve new Alzheimer’s drug

Alzheimer; News from the web:

Government health advisers sharply criticized a closely watched Alzheimer’s drug on Friday, concluding there wasn’t enough evidence that the experimental drug slowed the brain-destroying disease.

The panel of outside experts for the Food and Drug Administration agreed that a pivotal study in patients failed to show “strong evidence” that the drug worked. The experts warned of multiple “red flags” with the data, which did not initially show any benefit until another analysis with later results.

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First Alzheimer’s Blood Test Rolled Out for Clinical Use in US

Alzheimer; News from the web:

The first blood test designed to assist physicians in determining whether a patient has Alzheimer’s disease is now available in most US states, the company C2N Diagnostics announced October 29. The test measures biomarkers that frequently reflect the presence of amyloid plaques in the brain—a hallmark of Alzheimer’s—as well as the presence of a gene variant that increases the risk of the disease.

Read all about it HERE