New phase in a promising trial

Alzheimer; News from the web:

Alzamend Neuro has dosed the first patient in the multiple ascending dose portion of its Phase 2a clinical trial of AL001, an investigational oral therapy for dementia related to Alzheimer’s disease.

This multiple ascending dose (MAD) part follows positive results from a Phase 1 trial. Topline data from the Phase 2a trial is expected in December.

Read all about it HERE

You may be able to help Alzheimer’s research

Alzheimer; News from the web:

Now Enrolling: Sleep Intervention Study for Dementia Caregiving Pairs (The rePair Sleep Study) – OnlineEmory University researchers invite you to participate in Sleep Intervention Study for Dementia Caregiving Pairs (The rePair Sleep Study) a study to determine if cognitive behavioral therapy for insomnia is a practical and useful intervention for sleep problems. 

The rePair Sleep Study is researching the use of a cognitive behavioral interventional plan that is used to improve sleep quality for both caregivers and persons living with cognitive impairment. The intervention involves discussions centered on sleep and adjustment of sleep habits. The intervention will take place via videoconferencing for 7 online visits where participants will complete questionnaires, daily sleep diaries, and wear a watch to monitor their activity. 

Emory University researchers are looking for:

Persons with cognitive impairment who:Have a reported diagnosis of cognitive impairmentCo-reside with their caregiverHave sleep disturbancesCan read, speak and understand English Are willing to wear a wristwatch for 4 weeksAnd their caregiver who:Is an informal caregiver of co-residing person living with cognitive impairmentProvides unpaid caregiving assistance on average of 20 hours/week to person living with cognitive impairmentHas sleep disturbancesCan read, speak and understand EnglishIs willing to wear a wristwatch for 4 weeksThe caregiver and the person living with cognitive impairment will each receive a $25 gift card after completing the baseline visit, a $50 gift card after the completing the first post-intervention visit, and $25 after completing the 3-month post-intervention visit.

 For a full description of The rePair Sleep Study, please visit our website.
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Facts and figures about Alzheimer’s for 2022

Alzheimer; News from the web:

The number of Americans living with Alzheimer’s continues to rise. Currently, an estimated 6.5 million Americans age 65 and older are living with Alzheimer’s — about 1 in 9. By 2050, the number is projected to reach nearly 13 million.

This and more facts and figures in the annual report from the Alzheimer’s association.

Read all about it HERE

Outcomes of the Alzheimer’s research conference

Alzheimer; News from the web:

Alzheimer’s Research UK’s annual conference showcased the latest dementia research findings and allowed face-to-face collaboration for the first time since the COVID-19 pandemic.

600 of our inspirational dementia researchers, all at different points in their careers, shared the work they have been doing over the past few years. Here are some of the highlights!

Read all about it HERE

The importance of your sleep

Alzheimer; News from the web:

The brain’s ability to clear a protein closely linked to Alzheimer’s disease is tied to our circadian cycle, according to research published last week in PLOS Genetics.

The research underscores the importance of healthy sleep habits in preventing the protein Amyloid-Beta 42 from forming clumps in the brain, and opens a path to potential Alzheimer’s therapies.

Read all about it HERE

Alzheimer prevention registry

Alzheimer; News from the web:

The Alzheimer prevention registry sent us this:

Now Enrolling: The Brain Health Registry – Online

The purpose of the Brain Health Registry is to speed up the discovery of treatments for Alzheimer’s disease and other brain disorders. Joining the Brain Health Registry is easy. Participation takes less than three hours per year and can be completed entirely online.

If you choose to participate, you will be required to agree to a consent form. Once you give your consent, you will complete some questionnaires about your medical history, current health and lifestyle and take some online memory and thinking tests. You will be asked to come back every 6 months to answer more questions and take more tests. You may also have the opportunity to participate in additional research studies.

Brain Health Registry researchers are looking for people who are:

  • 18 years and older
  • Healthy volunteers, as well as those who have been diagnosed with Mild Cognitive Impairment, Alzheimer’s disease, or dementia

For a full description of the Brain Health Registry, please visit our website.

Will drinking coffee protect us from Alzheimer’s?

Alzheimer; News from the web:

  • There is currently no cure for Alzheimer’s disease, although treatment and lifestyle changes can slow its progression.
  • A new Australian study suggests that higher coffee intake might be linked to a slower rate of cognitive decline.
  • There was also an association between higher coffee intake and slower accumulation of amyloid deposits in the brain.

Read all about it HERE

New research details how Alzheimer’s starts

Alzheimer; News from the web:

Past research, mainly performed on animals, suggested the aggregates form in one region then spread throughout the brain, much like how cancer spreads.

The new study suggests that while such spread may occur, it’s not in fact the main driver of disease progression.

“Once we have these seeds, little bits of aggregate throughout the brain, they just multiply and that process controls the speed,” said Meisl.

An analogy from the COVID pandemic is how travel bans between nations generally proved ineffective at stopping the spread of the virus, because it was already replicating within the countries trying to keep it out.

The team was also able to determine the time it takes the aggregates to double in number — roughly five years. That is an “encouraging” figure, said Meisl, because it shows the brain’s neurons already are good at countering aggregates. 

“Maybe if we can make it just a tiny bit better we can significantly delay the onset of serious disease.”

Read all about it HERE

Alzheimer’s and Covid; a connection found

Alzheimer; News from the web:

Researchers have identified a genetic link between Alzheimer’s and severe cases of COVID-19 that may open new avenues into the treatment of both diseases.

The study, published in the journal Brain , found that the presence of a variant of the OAS1 gene increases the risk of developing Alzheimer’s disease by three to six per cent, while similar variants of the same gene increase the odds of contracting a case of severe COVID. In addition to presenting new possibilities for treatment, researchers hope this overlap may shed light on other infectious diseases and dementias.

Read all about it HERE

Alzheimer’s therapy for people with Down syndrome

Alzheimer; News from the web:

Researchers at the University of Colorado School of Medicine have been awarded a $4.6 million, five-year grant by the National Institute on Aging to study whether a potential Alzheimer’s disease treatment is safe and effective in improving cognitive function in young adults with Down syndrome.

Huntington Potter, PhD, professor of neurology, and Peter Pressman, MD, assistant professor of neurology, are principal investigators on the study of sargramostim, which is also know by the brand name Leukine, an FDA-approved drug with nearly 30 years of safe use in numerous patient populations.

“This is the first clinical trial in years to target cognition in people with Down syndrome,” said Potter, who is director of University of Colorado Alzheimer’s and Cognition Center. “We are breaking new ground in studying both of these disorders – Down syndrome and Alzheimer’s disease. We hope that this therapy will greatly improve their quality of life.”

Read all about it HERE

The importance of sleep in a new study

Alzheimer; News from the web:

Disrupted sleep is common in late life, the study authors wrote, and associated with changes in cognitive function — the mental capacity for learning, thinking, reasoning, problem-solving, decision-making, remembering and paying attention.Age-related changes in sleep have also been linked with early signs of Alzheimer’s disease, depression and cardiovascular disease, so the authors investigated possible associations between self-reported sleep duration, demographic and lifestyle factors, subjective and objective cognitive function, and participants’ levels of beta amyloid.

Read all about it HERE

Key mechanisms behind synapse degeneration in Alzheimer’s brain discovered

Alzheimer; News from the web:

Neurobiologists have uncovered the long-sought-after mechanisms behind the maintenance and decline of key synapses implicated in brain disorders such as Alzheimer’s disease. The researchers identified the main components driving amyloid beta-associated synapse degeneration, which is found in the brains of people with Alzheimer’s. The findings suggest an alternative approach to addressing neurodegenerative disorders: protect synapses by directly blocking the toxic actions of amyloid beta.

Read all about it HERE

Finally a cure?

Alzheimer; News from the web:

A drug called aducanumab could become the first approved treatment designed to alter the course of Alzheimer’s disease rather than relieve symptoms.

But it’s unclear whether the Food and Drug Administration will approve the drug because of persistent questions about its effectiveness.

Read all about it HERE

‘Rejuvenating’ the Alzheimer’s brain

Alzheimer; News from the web:

Alzheimer’s disease is the main cause of dementia and current therapeutic strategies cannot prevent, slow down or cure the pathology. The disease is characterized by memory loss, caused by the degeneration and death of neuronal cells in several regions of the brain, including the hippocampus. Researchers have identified a small molecule that can be used to rejuvenate the brain and counteract the memory loss.

Read all about it HERE

Air quality may impact Alzheimer’s

Alzheimer; News from the web:

Researchers at the University of California, Davis, have found a link between traffic-related air pollution and an increased risk for age-related dementia, including Alzheimer’s disease. Their study, based on rodent models, corroborates previous epidemiological evidence showing this association.

Read all about it HERE

AI can help Alzheimer’s

Alzheimer; News from the web:

Have you ever wondered how Netflix knows the perfect show to recommend next? Or how Facebook suggests just the person you were looking to follow? 

Researchers have found the power of those predicting algorithms can also “predict” the biological language of cancer and neurodegenerative diseases like Alzheimer’s – which could help change completely what researchers know about treating and preventing such diseases.

Read all about it HERE

13 Alzheimer’s gene variants found

Alzheimer; News from the web:

Researchers have identified 13 variants of genes connected to Alzheimer’s disease that are new to scientists. In a study published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, the researchers report how they sequenced whole genomes of people in more than 600 families with individuals who have been diagnosed with Alzheimer’s and searched for rare versions of genes.

Read all about it HERE