“The brain damage from Alzheimer’s makes people prone to agitation regardless of how loving caregivers are,” said Stefanacci, who also specializes in older populations and Alzheimer’s.

According to information the Alliance of Aging Research sent to HuffPost, “agitation” in this sense can present itself in a variety of ways: pacing, trying to leave, angry outbursts, profanity, hitting, mood swings, throwing items and more. Caregivers may blame themselves, AAR continued, thinking it’s a result of their burnout, introducing a new routine or not being patient enough. 

Scientists have created the most detailed maps yet of how genes control one another inside the brains of people with Alzheimer’s disease. Using a powerful new AI-based system called SIGNET, the team uncovered cause-and-effect relationships between genes across six major brain cell types, revealing which genes are truly driving harmful changes. The most dramatic disruptions were found in excitatory neurons, where thousands of genetic interactions appear to be extensively rewired as the disease progresses.

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