Overly optimistic about a cure for Alzheimer’s?

Alzheimer; News from the web:

This is the most important column I’ve ever written.  The message is quite complex–dozens of new health parameters to test for and to optimize, all of them interacting in ways that will require new training for MDs.  The message is also as simple as it can be: There is a cure for Alzheimer’s disease. You can stop reading right here, and buy two copies of Dale Bredesen’s book, one for you and one for your doctor:  The End of Alzheimer’s.

Read all about it HERE

The best defense is attack or in this case, prevention of Alzheimer’s

Alzheimer; News from the web:

It may be too late to stop Alzheimer’s in people who already have some mental decline. But what if a treatment could target the very earliest brain changes while memory and thinking skills are still intact, in hope of preventing the disease? Two big studies are going all out to try.

Clinics throughout the United States and some other countries are signing up participants — the only studies of this type enrolling healthy older people.

Read all about it HERE

Ah, this is why all those tests failed

Alzheimer; News from the web:

Researchers at King’s College London have discovered a vicious feedback loop underlying brain degeneration in Alzheimer’s disease which may explain why so many drug trials have failed. The study also identifies a clinically approved drug which breaks the vicious cycle and protects against memory-loss in animal models of Alzheimer’s.

Read all about it HERE

Alzheimer’s, who is more at risk, ladies or gentlemen?

Alzheimer; News from the web:

Women are more likely to have Alzheimer’s disease than men, according to the Alzheimer’s Society.

There’s a higher risk in women, even after discounting their longer life expectancy.

The exact reason why women are more at risk of the dementia isn’t entirely understood, but it’s believed to be related to their genetic makeup.

But, men are more likely to develop vascular dementia, the charity warned.

“Some risk factors for dementia can’t be changed,” it said. “The most important are a person’s age, genes, sex and ethnic origin.

“Women are more likely to develop Alzheimer’s disease than men [even allowing for the fact that women on average live longer]. Continue reading

This is how exercise works for (against) Alzheimer’s

Alzheimer; News from the web:

A study by a Massachusetts General Hospital (MGH) research team finds that neurogenesis -inducing the production of new neurons — in the brain structure in which memories are encoded can improve cognitive function in a mouse model of Alzheimer’s disease. Their investigation shows that those beneficial effects on cognition can be blocked by the hostile inflammatory environment present in the brain of patients with Alzheimer’s disease and that physical exercise can “clean up” the environment, allowing new nerve cells to survive and thrive and improving cognition in the Alzheimer’s mice.

Read all about it HERE

Even one day can do damage

Alzheimer; News from the web:

The researchers, studying rodent models, found that the more complex a memory is, the greater the risk that it will be compromised by a high-fat diet. The study demonstrates that such a diet causes deficits in episodic, spatial and contextual memory.

Episodic memory (those that provide context, such as ‘what, when, who and where’) is important in humans as it is one of the first types of memory to be compromised in Alzheimer’s disease and deficits in this memory type have been linked to a higher body mass index in young adults.

Read all about it HERE

This drug may help if used before you get symptoms

Alzheimer; News from the web:

“I don’t want to raise false hopes,” Researcher Bloom said, but “if this idea of using memantine as a prophylactic pans out, it will be because we now understand that calcium is one of the agents that gets the disease started, and we may be able to stop or slow the process if done very early.”

Read all about it HERE

About hope

Alzheimer; News from the web:

Is it good to get our hopes up with every bit of good news, or is the disappointment when it turns out not to be the magic bullet too much?

A promising new drug called BAN2401 generated a lot of excitement after a clinical trial found it slowed the progression of Alzheimer’s by 30%, but recent revelations have left investors and doctors with more questions than answers, reports Bloomberg.

Read all about it HERE

Skinny-fat may indicate Alzheimer’s

Alzheimer; News from the web:

You can’t tell how healthy someone is just by looking at them, but that doesn’t mean people don’t make assumptions, especially when they’re factoring in weight. But what about people who are “skinny-fat”? According to a new study, this body type, which is characterized by a combination of high fat mass and low muscle mass, may actually be worse for your health than obesity alone.

Read all about it HERE