Research takes another path

Alzheimer; News from the web:

For years researchers have been guided by one leading theory — that getting rid of a buildup of a sticky protein called amyloid would ease the mind-robbing disease. Yet drug after drug has failed. They might clear out the gunk, but they’re not stopping Alzheimer’s inevitable worsening.

The new mantra: diversify.

With more money — the government had a record $2.4 billion to spend on Alzheimer’s research this year — the focus has shifted to exploring multiple novel ways of attacking a disease now considered too complex for a one-size-fits-all solution. On the list, researchers are targeting the brain’s specialized immune system, fighting inflammation, even asking if simmering infections play a role.

Some even are looking beyond drugs, testing if electrical zaps in the brain, along a corridor of neural connections, might activate it in ways that slow Alzheimer’s damage.

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Help Alzheimer’s research

Alzheimer; News from the web:

Recently, the Alzheimer’s Association’s created the TrialMatch program, through which 250 studies are recruiting participants. This is a way to learn about trials in your region, whether you may qualify, and how to participate.It has been referred to as a “dating service” – matching up people with clinical trials for which they are a good fit.

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Why do you get sleepy during the day?

Alzheimer; News from the web:

Extreme daytime sleepiness is often a top symptom of Alzheimer’s disease but what, exactly, causes it? New research finally brings us an answer. A new study, conducted by researchers at the University of California, San Francisco (UCSF) and other institutions, shows that people with Alzheimer’s disease experience major brain cell loss in regions of the brain tasked with keeping us awake.

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Good early results on a Alzheimer’s vaccine

Alzheimer; News from the web:

Interim results of a clinical trial on an Alzheimer’s vaccine being tested on Down syndrome individuals are promising, say researchers at the Swiss clinical-stage biopharmaceutical company AC Immune. The company’s liposomal therapeutic anti-Abeta vaccine, dubbed ACI-24, is also being evaluated in mild to moderate Alzheimer’s patients in a Phase 2 study.

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Know the signs and talk about it

Alzheimer; News from the web:

A survey released this week by the Alzheimer’s Association finds that nearly 90 percent of Americans say they would want others to tell them if they were showing signs of memory loss or other symptoms of dementia. And yet, nearly three quarters of Americans say having that conversation would be “challenging” for them.

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Alzheimer’s Facts and Statistics for 2019: Everything You Need to Know

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The 2019 Alzheimer’s Disease Facts and Figures Report reveals that one in 10 Americans age 65 or older have Alzheimer’s disease. While researchers look for an Alzheimer’s cure, the Alzheimer’s Drug Discovery Foundation (ADDF) recently awarded $3.5 million to researchers focused on promising early-detection Alzheimer’s tests ranging from blood tests to eye tests that can diagnose Alzheimer’s early and affordably. The latest Alzheimer’s disease facts and statistics illustrate why researchers are determined to find a cure or halt the disease’s progression. Ahead, some interesting facts about Alzheimer’s, and your guide to the most common questions.

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Status of Alzheimer’s research

Alzheimer; News from the web:

There are roughly 326 active, recruiting or enrolling by invitation clinical trials on the elusive disease, per clinicaltrial.gov. The U.S. last year dramatically stepped up funding for Alzheimer’s disease research, from $400 million a year to over $2 billion annually, although the Alzheimer’s Association says more is needed.

The biggest problem: Scientists still don’t know the cause of Alzheimer’s.

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Risk of Alzheimer’s when it hits extended family members

Alzheimer; News from the web:

In line with previous studies, the researchers found that having one or more first-degree relatives with Alzheimer’s put people at significantly higher risk for the disease. People with one first-degree relative with Alzheimer’s were 1.73 times more likely to develop the disease. Looking further into the family tree, people with two first-degree relatives with Alzheimer’s were nearly four times more likely to develop the disease. Those with three first-degree relatives were nearly two-and-half more times likely, and those with four were almost 15 times more likely to develop Alzheimer’s disease.

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Accelerating Alzheimer’s research

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A team of researchers at the Human Computation Institute and Cornell University seek to understand what causes a 30% reduction of blood flow to the brain in Alzheimer’s patients.

Preliminary findings from the Schaffer-Nishimura Biomedical Engineering Lab suggest that restoring blood flow to the brain could delay the onset of Alzheimer’s and restore cognitive functioning. But there is too much data to sift through, and the blood flow imagery is too subtle for most algorithms to classify into capillaries that are either flowing or stalled. So instead, citizen scientists are helping analyze the videos in a gamified effort called “Stall Catchers” — and, through this crowdsourcing effort, are doing so at a much faster rate than the lab.

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