Get up and prevent Alzheimer’s

Alzheimer; News from the web:

In a first-of-its-kind study, researchers have found that in people middle-aged and older, a brain structure that is key to learning and memory is plumpest in those who spend the most time standing up and moving. At every age, prolonged sitters show less thickness in the medial temporal lobe and the subregions that make it up, the study found.

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Major fix for Alzheimer’s found

Alzheimer; News from the web:

Scientists have recently made a major discovery that could lead to a breakthrough in the treatment of Alzheimer’s disease. A recent study published in Nature Medicine reports that researchers were able to identify the primary genetic risk factor the development of the disease, and they even figured out a potential way to neutralize the risk factor.

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They call it “sundowning”

Alzheimer; News from the web:

A new study has uncovered a biological clock circuit that may explain why people with Alzheimer’s disease or other forms of dementia can become more agitated or aggressive in the early evening.
senior lady at night

People with Alzheimer’s can feel more agitated during the evening.

The researchers hope that their findings will lead to new treatments that help to calm the aggressiveness and agitation that individuals with Alzheimer’s and other neurodegenerative diseases commonly experience as part of a condition known as “sundowning.”

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OK for a mouse but not for man

Alzheimer; News from the web:

One of the more vexing problems bedeviling Alzheimer’s research is why so many treatments that are successful in mouse models fail in clinical trials with humans. In a paper published yesterday in Nature Medicine, a team of researchers at the Gladstone Institutes identified how a key genetic variant associated with the development of Alzheimer’s operates differently in mice and humans. They also showed that the problematic gene can be repaired.

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New biomarkers for Alzheimer’s found

Alzheimer; News from the web:

Research from the University of Texas at San Antonio suggests that the plaques that cause the symptoms of Alzheimer’s disease may be more complicated than previously believed, a finding that could significantly affect drug development for the disease.

Researchers found that in addition to the sticky proteins called amyloid beta, other neural and repair proteins also exist within the plaques, indicating new biomarkers for the disease that affects more than 5 million people in the United States.

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ibuprofen against Alzheimer’s

Alzheimer; News from the web:

The over-the-counter drug reduces inflammation in the brain, caused by a build up of rogue proteins that lead to memory loss and confusion.

If started early enough, a daily pill could reduce the chance of dementia in those most at risk.

Scientists said a simple saliva test could be used to find those people who could benefit.

They would then be put on a regular low dose of the painkiller for the rest of their lives.

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Big brother may come to watch over you

Alzheimer; News from the web:

Spotting the first indications of Alzheimer’s years before any obvious symptoms come on could help pinpoint people most likely to benefit from experimental drugs and allow family members to plan for eventual care. Devices equipped with such algorithms could be installed in people’s homes or in long-term care facilities to monitor those at risk. For patients who already have a diagnosis, such technology could help doctors make adjustments in their care.

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“Beeting” Alzheimer’s disease

Alzheimer; News from the web:

Funny play on words from the authors from Phys.org but the topic is serious enough.

A compound in beets that gives the vegetable its distinctive red color could eventually help slow the accumulation of misfolded proteins in the brain, a process that is associated with Alzheimer’s disease. Scientists say this discovery could lead to the development of drugs that could alleviate some of the long-term effects of the disease, the world’s leading cause of dementia.

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New research promising for prevention of cognitive decline

Alzheimer; News from the web:

A new study from The University of Texas Medical Branch at Galveston has provided researchers important insights about an enzyme within the brain that plays a critical role in Alzheimer’s.

The UTMB researchers found that blocking the enzyme helped prevent memory loss in mice.

The enzyme is a promising target for developing medications to prevent cognitive decline. The study was recently published in Alzheimer’s and Dementia: Translational Research and Clinical Interventions.

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No drugs but instead…..

Alzheimer; News from the web:

The current Alzheimer’s clinical research impasse has encouraged more doctors to pursue non-pharmacological alternatives. For most individuals — beyond the up-to-5-percent who are genetically predisposed to early onset Alzheimer’s — focusing on lifestyle factors as the key to brain fitness and cognitive function, they say, is wiser than waiting for a breakthrough delivered in a pill.

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Alzheimer’s researchers win brain prize

Alzheimer; News from the web:

Four dementia scientists have shared this year’s 1m Euro brain prize for pivotal work that has changed our understanding of Alzheimer’s disease.

Profs John Hardy, Bart De Strooper, Michael Goedert, based in the UK, and Prof Christian Haass, from Germany, unpicked key protein changes that lead to this most common type of dementia.

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Alzheimer’s predictions

Alzheimer; News from the web:

Heart disease deaths have actually decreased 14 percent since 2000, while Alzheimer’s deaths have increased 89 percent. Of the diseases listed in the 10 leading causes of death in the United States, Alzheimer’s is the only one that can’t be prevented, slowed or cured.

But on the positive side, there is a bloodtest in preparation that will warn you  about 20 ahead of any symptoms.

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Disco against Alzheimer’s

Alzheimer; News from the web:

In March 2015, Li-Huei Tsai set up a tiny disco for some of the mice in her laboratory. For an hour each day, she placed them in a box lit only by a flickering strobe. The mice — which had been engineered to produce plaques of the peptide amyloid-β in the brain, a hallmark of Alzheimer’s disease — crawled about curiously. When Tsai later dissected them, those that had been to the mini dance parties had significantly lower levels of plaque than mice that had spent the same time in the dark1.

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Fish oil reviewed

Alzheimer; News from the web:

A new study about the impact of Fish Oil on Alzheimer’s is underway.

Researchers are concentrating on how the fish oil helps with brain blood flow and how it affects key proteins related to the development of Alzheimer’s, particularly amyloids.

“We’re focusing on a fish oil that we know helps improve blood flow and helps reduce cholesterol levels, to see if that helps beneficially change some of these markers,” s

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Is the end of Alzheimer’s near?

Alzheimer; News from the web:

More research will need to get done but for now, at least the mice have found a cure for Alzheimer’s. It involves removing one enzyme in the brain. This cleared out all the amyloid plaques which is often seen as the main cause of Alzheimer’s disease. Some other studies though, suggest that working on the amyloid plaques is the wrong target and they may not be the eventual cause for Alzheimer’s.

In any case, even if this new development would be transferable to humans, it will take another five to seven years before we could see it in doctor’s hands for treatments.

It is a long road, we continue to monitor its progress.

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