Success with fruit flies!

Alzheimer; News from the web:

Researchers have reversed symptoms of Alzheimer’s disease in fruit flies by adjusting the production of certain enzymes. The finding may open doors to exploring epigenetics as a potential avenue for Alzheimer’s disease treatments

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Animal memory may help Alzheimer’s research

Alzheimer; News from the web:

Have you ever looked at your dog or cat and wondered whether it can remember that you recently rewarded or scolded them — and when that happened?

Indiana University neuroscientists have discovered what they say is the first evidence nonhuman animals can replay a stream of past events from memory — and even the sequence in which those events occurred.

The discovery of this type of episodic memory in rodents may someday help advance the development of new drugs to treat Alzheimer’s disease, said Jonathon Crystal, a professor and director of the neurosciences program at IU-Bloomington

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Funding Alzheimer’s with some spare change

Alzheimer; News from the web:

“While spare change doesn’t seem like a lot, automatically rounding up one’s transaction adds up to about $50 per month on average,” Tokarsky said. “Just think about it. Does it really make sense for millions of people to wait around to die from a horrible disease, simply because one can’t make a profit developing a cure? Doesn’t it make more sense to invest our spare change, regardless if we make money or lose it, but so that we have a pretty decent chance for a cure in 5, 10 or 15 years?”

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Please volunteer for Alzheimer’s research

Alzheimer; News from the web:

A momentous scientific study focused on early detection of Alzheimer’s disease, and tracking it over time, seeks healthy volunteers without memory problems, as well as people who have mild memory problems and those who have been diagnosed with mild dementia due to Alzheimer’s disease.

Potential study volunteers can learn more by visiting www.ADNI3.org or by calling 1-888-2-ADNI-95 (1-888-223-6495).

Read all about it HERE

Alzheimer; News from the web:

Interesting story from the NYtimes:

In the next three minutes, three people will develop Alzheimer’s disease. Two of them will be women.

There are 5.7 million Alzheimer’s patients in the United States. By 2050, there will probably be as many as 14 million, and twice as many women as men will have the disease.

And yet research into “women’s health” remains largely focused on reproductive fitness and breast cancer. We need to be paying much more attention to the most important aspect of any woman’s future: her ability to think, to recall, to imagine — her brain.

Read all about it HERE

Get up and prevent Alzheimer’s

Alzheimer; News from the web:

In a first-of-its-kind study, researchers have found that in people middle-aged and older, a brain structure that is key to learning and memory is plumpest in those who spend the most time standing up and moving. At every age, prolonged sitters show less thickness in the medial temporal lobe and the subregions that make it up, the study found.

Read all about it HERE

Major fix for Alzheimer’s found

Alzheimer; News from the web:

Scientists have recently made a major discovery that could lead to a breakthrough in the treatment of Alzheimer’s disease. A recent study published in Nature Medicine reports that researchers were able to identify the primary genetic risk factor the development of the disease, and they even figured out a potential way to neutralize the risk factor.

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They call it “sundowning”

Alzheimer; News from the web:

A new study has uncovered a biological clock circuit that may explain why people with Alzheimer’s disease or other forms of dementia can become more agitated or aggressive in the early evening.
senior lady at night

People with Alzheimer’s can feel more agitated during the evening.

The researchers hope that their findings will lead to new treatments that help to calm the aggressiveness and agitation that individuals with Alzheimer’s and other neurodegenerative diseases commonly experience as part of a condition known as “sundowning.”

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OK for a mouse but not for man

Alzheimer; News from the web:

One of the more vexing problems bedeviling Alzheimer’s research is why so many treatments that are successful in mouse models fail in clinical trials with humans. In a paper published yesterday in Nature Medicine, a team of researchers at the Gladstone Institutes identified how a key genetic variant associated with the development of Alzheimer’s operates differently in mice and humans. They also showed that the problematic gene can be repaired.

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New biomarkers for Alzheimer’s found

Alzheimer; News from the web:

Research from the University of Texas at San Antonio suggests that the plaques that cause the symptoms of Alzheimer’s disease may be more complicated than previously believed, a finding that could significantly affect drug development for the disease.

Researchers found that in addition to the sticky proteins called amyloid beta, other neural and repair proteins also exist within the plaques, indicating new biomarkers for the disease that affects more than 5 million people in the United States.

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ibuprofen against Alzheimer’s

Alzheimer; News from the web:

The over-the-counter drug reduces inflammation in the brain, caused by a build up of rogue proteins that lead to memory loss and confusion.

If started early enough, a daily pill could reduce the chance of dementia in those most at risk.

Scientists said a simple saliva test could be used to find those people who could benefit.

They would then be put on a regular low dose of the painkiller for the rest of their lives.

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Big brother may come to watch over you

Alzheimer; News from the web:

Spotting the first indications of Alzheimer’s years before any obvious symptoms come on could help pinpoint people most likely to benefit from experimental drugs and allow family members to plan for eventual care. Devices equipped with such algorithms could be installed in people’s homes or in long-term care facilities to monitor those at risk. For patients who already have a diagnosis, such technology could help doctors make adjustments in their care.

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“Beeting” Alzheimer’s disease

Alzheimer; News from the web:

Funny play on words from the authors from Phys.org but the topic is serious enough.

A compound in beets that gives the vegetable its distinctive red color could eventually help slow the accumulation of misfolded proteins in the brain, a process that is associated with Alzheimer’s disease. Scientists say this discovery could lead to the development of drugs that could alleviate some of the long-term effects of the disease, the world’s leading cause of dementia.

Read all about it HERE