Alzheimer; News from the web:
The biotech world went into a full-on frenzy Tuesday when drug giant Biogen dropped this whopper: The company is reviving its Alzheimer’s drug hopeful, aducanumab, after leaving it for dead all the way back in March. In fact, it’s marching forward with a Food and Drug Administration (FDA) application to approve the drug for certain patients facing cognitive decline.
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Alzheimer; News from the web:
Alzheimer’s symptoms are diminishing due to a treatment with ultrasound to allow medicine to get through the blood-brain barrier.
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Alzheimer; News from the web:
This article from the Guardian brings us five ways to slow down Alzheimer’s onset. For details see the article in our link for today.
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Alzheimer; News from the web:
Researchers have now found that slower loss of cognitive skills in people with AD correlates with higher levels of a protein that helps immune cells clear plaque-like cellular debris from the brain [1]. The efficiency of this clean-up process in the brain can be measured via fragments of the protein that shed into the cerebrospinal fluid (CSF). This suggests that the protein, called TREM2, and the immune system as a whole, may be promising targets to help fight Alzheimer’s disease.
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Alzheimer; News from the web:
A Birmingham nonprofit organization connects Alzheimer’s, dementia patients with art, see it in our link for today.
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Alzheimer; News from the web:
The drug company Biogen is asking the FDA to approve one of its Alzheimer’s treatments, a sign that clinical trials have shown success for the therapy. The drug, aducanumab, is still in the experimental stages, and Biogen had thrown in the towel months ago when studies didn’t seem to show progress. The company now says higher doses may be key. An Alzheimer’s drug gaining FDA approval would be blockbuster. There are currently no effective treatments for the memory-robbing disease, which affects more than 5 million people in the U.S. alone
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Alzheimer; News from the web:
Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified a possible treatment for Alzheimer’s disease. Working together with a scientific team at the Rockefeller University in New York, the investigators have shown that treatment with the oral anticoagulant dabigatran delays the appearance of Alzheimer’s disease in mice.
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Alzheimer; News from the web:
An open-label clinical trial working with eight people with Alzheimer’s disease concluded that a new wearable device that emits electromagnetic impulses was able to significantly improve memory loss in seven of these participants within 2 months.
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Alzheimer; News from the web:
The only way to fight off Alzheimer’s is called:
SHIELD
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Alzheimer; News from the web:
Read the story about how the FDA and their approval system can get in the way of treatments that have shown to be effective in other countries and seem safe to use.
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Alzheimer; News from the web:
Good article by the LA Times and they review the failed drug tests and then go into what will actually work to stave off Alzheimer’s without providing a real cure, but just the best practices we now know.
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Alzheimer; News from the web:
Read the heartwarming story of how people with dementia can relive their past by biking through familiar places, or exploring new ones, while not leaving their home.
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Alzheimer; News from the web:
Researchers have found that nilvadipine, a drug that doctors regularly use to treat hypertension, may help people with Alzheimer’s disease by increasing blood flow to the brain.
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Alzheimer; News from the web:
Alzheimer’s drugs cost seven times more than cancer drugs to develop
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Alzheimer; News from the web:
Here is a new drug that seemed effective for mice and now has been found safe for humans, so the next step it to test it on patients with Alzheimer’s. Exciting times
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Alzheimer; News from the web:
In 2016, to the surprise of Alzheimer’s disease researchers across the world, a team at the Massachusetts Institute of Technology found that setting mice in front of a blinking light could clear out the characteristic protein plaques thought to be one of the roots of the disease. A recent follow up study found that sounds played at a particular frequency clearned plaques and improved cognition, as well.
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Alzheimer; News from the web:
Let’s start with a hard truth: While certain FDA-approved drugs can treat the symptoms, no cures or treatments have been shown to stop, slow or reverse the progression of Alzheimer’s disease, the most common form of dementia. The FDA is clamping down on the makers of dozens of products, often labelled as dietary supplements, that claim otherwise. What those companies are selling, says the administration, is false hope.
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Alzheimer; News from the web:
Alzheimer’s disease is a progressive, incurable brain disorder that slowly robs the sufferer of memory and cognitive functions, eventually claiming the ability to carry out even simple tasks.
Yet, it’s been noted that music can sometimes evoke responses from Alzheimer’s patients when nothing else can.
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Alzheimer; News from the web:
NeuroTherapia Inc. will start clinical trials of a new drug targeting inflammation of the brain that’s found in Alzheimer’s and other neurological diseases, according to a news release.
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Alzheimer; News from the web:
Just as genetic makeup plays a role in the risk for Alzheimer’s, new drugs designed to alter your genes could bring us closer to a cure.
The concept is called epigenetics, and one of the more promising drugs in this new avenue of Alzheimer’s research is now being studied in New Jersey.
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Alzheimer; News from the web:
The hopeful quote:
“We have reason to believe that not only can it reverse the effects of Alzheimer’s, but possibly prevent the effects from occurring in the beginning,” Dr Hatchuel said.
“It has the potential to change the lives of 50 million people across the world, which is absolutely ground breaking.”
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Alzheimer; News from the web:
Most people with dementia have a number of brain abnormalities, not just Alzheimer’s disease. The finding is forcing scientists to rethink the search for treatments.
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Alzheimer; News from the web:
New research at the University of Warwick is now underway to “prove” how curcumin can induce autophagy to prevent Alzheimer’s, after initial tests showed positive results.
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Alzheimer; News from the web:
As powerful as the human brain is, once it’s damaged it can’t really recover completely. Now researchers at Penn State may have found a way to boost the brain’s regenerative abilities, using certain molecules to convert neighboring cells into new neurons. The technique could eventually lead to pills that treat brain injuries, stroke or Alzheimer’s disease.
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Alzheimer; News from the web:
Despite Roche’s recent trial failure for crenezumab, the ProMIS team remain confident a disease-modifying treatment will be found in the next decade.
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Alzheimer; News from the web:
In a small lab in Jackson Hole, Wyo., 65-year-old Paul Cox believes he’s closing in on a treatment that might prevent Alzheimer’s disease. And ALS. And a host of other neurodegenerative diseases, for that matter. Cox, we should point out, isn’t a neurologist. He isn’t a physician of any kind. He doesn’t work at a big drug company or an academic medical center or a government laboratory. His ideas come from so far outside the mainstream of neurological research that you might think he’s crazy or deluded or worse. But then, some very credible people think he might be on to something big—which might make the improbable, quixotic story you are about to read one of the most important as well.
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Alzheimer; News from the web:
Whether royal jelly has genuine health benefits for humans is a matter for more research, but in a study scientists have cracked one of the most enduring puzzles surrounding the milky gloop: the secret behind its queen-maker magic.
The discovery promises to have an impact far beyond the niche field of melittology. Armed with the findings, scientists are now exploring potential new treatments for wounds and disorders such as muscle wastage and neurodegenerative disease.
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Alzheimer; News from the web:
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