Alzheimer; News from the web:
The results of the clinical studies submitted by the drug’s manufacturer, Biogen, and the FDA’s accelerated approval, have been highly criticized by experts in the field.
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Alzheimer; News from the web:
A plant commonly found in Indian gardens could hold molecules to treat Alzheimer’s, a brain disease that severely affects behavior and memory, said researchers in Bengaluru.
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Alzheimer; News from the web:
With the new approved drug for Alzheimer’s there is now the issue of what it will cost and how you’ll be able to afford it.
Biogen said the drug would cost approximately $56,000 for a typical year’s worth of treatment, and it said the price would not be raised for four years.
Medicare is widely expected to cover the treatment. Insurers that offer private or commercial coverage also will pay for care that doctors deem medically necessary.
That may not mean every case, though. If the treatment is proposed for a patient with advanced Alzheimer’s, and research shows the drug isn’t effective in that population, then the insurer may not pay for it.
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Alzheimer; News from the web:
Truly great news today, the new drug Aducanumab has been approved by the FDA for use in early Alzheimer’s cases.
The drug was developed for patients with mild cognitive impairment, not severe dementia, and intended to slow progression of Alzheimer’s disease — not just ease symptoms.
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Alzheimer; News from the web:
A drug called aducanumab could become the first approved treatment designed to alter the course of Alzheimer’s disease rather than relieve symptoms.
But it’s unclear whether the Food and Drug Administration will approve the drug because of persistent questions about its effectiveness.
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Alzheimer; News from the web:
Alzheimer’s disease is the main cause of dementia and current therapeutic strategies cannot prevent, slow down or cure the pathology. The disease is characterized by memory loss, caused by the degeneration and death of neuronal cells in several regions of the brain, including the hippocampus. Researchers have identified a small molecule that can be used to rejuvenate the brain and counteract the memory loss.
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Alzheimer; News from the web:
Low-dose ionizing radiation may be a promising, although possibly controversial, therapy for Alzheimer’s disease, according to the researchers behind a small new pilot study.
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Alzheimer; News from the web:
What if we think of Alzheimer’s not as one disease, but three separate ones, with overlapping symptoms? Researchers behind a new study say Alzheimer’s encapsulates three distinct molecular conditions, and that a better understanding of each could be a lifeline for failed Alzheimer’s treatment efforts and future research.
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Alzheimer; News from the web:
Exercising regularly has many health benefits, but did you know aerobic exercise could also benefit older adults living with Alzheimer’s dementia?
https://www.timesnownews.com/
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Alzheimer; News from the web:
In 2018, a research group led by David Holtzman, M.D., at Washington University in St. Louis developed an antibody drug in collaboration with Denali Therapeutics that showed promise as a potential Alzheimer’s disease therapy. Now, the team has returned with mouse data suggesting the drug prospect might be a safer option than Biogen’s much-hyped aducanumab.
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Alzheimer; News from the web:
Twenty Veterans with Alzheimer’s disease and apathy took part in a pilot study. Half received repetitive transcranial magnetic stimulation (rTMS), a type of brain stimulation. The others received sham stimulation, basically a placebo.
Through patient and caregiver interviews, the VA team documented “significantly greater improvement” in apathy levels in those who received brain stimulation compared with the control group. The positive effects continued up to three months.
Besides improvements in apathy, the researchers also noted “significantly greater improvement” in memory, attention, and cognition in the rTMS patients compared with the sham treatment group.
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Alzheimer; News from the web:
Government health advisers sharply criticized a closely watched Alzheimer’s drug on Friday, concluding there wasn’t enough evidence that the experimental drug slowed the brain-destroying disease.
The panel of outside experts for the Food and Drug Administration agreed that a pivotal study in patients failed to show “strong evidence” that the drug worked. The experts warned of multiple “red flags” with the data, which did not initially show any benefit until another analysis with later results.
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Alzheimer; News from the web:
Read the message from the Alzheimer’s association to the FDA, supporting approval of the drug.
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Alzheimer; News from the web:
Targeting recall processes could let people who are in the disease’s early stages access what they currently can’t remember
Scientific American
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Alzheimer; News from the web:
The first infusion of an investigational drug that aims to delay or help to prevent the earliest memory loss due to Alzheimer’s disease took place in September at Butler Hospital in Providence, R.I., researchers announced.
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Alzheimer; News from the web:
A new study from a Penn researcher adds to evidence that a class of antidepressant drugs known as SSRIs may reduce production of a key protein found in the brains of people with Alzheimer’s disease. This is evidence, she said, that the drugs could someday be part of a cocktail used to prevent or delay this form of dementia.
www.inquirer.com
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Alzheimer; News from the web:
The first drug shown to potentially delay the progression of Alzheimer’s disease could be approved next year.
The Food and Drug Administration (FDA) in the United States said that aducanumab had been accepted for a priority review process.
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Alzheimer; News from the web:
Scientists discover for the first time that oxytocin could be a potential new therapeutic option for cognitive disorders such as Alzheimer’s disease.
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Alzheimer; News from the web:
This sounds like good news. Scientists have found a way to speed up the testing of Alzheimer’s drugs.
Alzheimer’s clinical trials may take decades, but a new discovery could cut clinical trial time down to a matter of weeks.
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Alzheimer; News from the web:
A laboratory study has found that the asthma drug salbutamol prevents the formation of tangles of fibrous protein that are a hallmark of Alzheimer’s disease. The next step will be to test the drug in animal models of the disease.
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Alzheimer; News from the web:
The Alzheimer’s foundation provides a helpline for caregivers in over 90 languages!
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Alzheimer; News from the web:
A team of scientists from the Georgia Institute of Technology in Atlanta has discovered some reasons why lights flickering at 40 beats per second, or 40 hertz (Hz), have a beneficial effect on Alzheimer’s disease.
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Alzheimer; News from the web:
A new study published in the journal Neurology in January 2020 concludes that increasing the intake of plant flavonols steeply reduces the risk of Alzheimer’s dementia (AD) by up to a half. In other words, AD could be prevented in many people simply by regularly eating and drinking more foods containing these compounds such as tea, oranges and broccoli.
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Alzheimer; News from the web:
Lithium is well known in the treatment of psychiatric conditions and now researchers have found that a micro dose of it can be beneficial in the treatment of Alzheimer’s, even in later stages of the disease.
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Alzheimer; News from the web:
Studies by researchers at the Lighting Research Center at Rensselaer Polytechnic Institute in New York showed that light therapy tailored to increase the circadian stimulation during the day benefited individuals with Alzheimer’s disease or dementia living in long-term care settings.
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Alzheimer; News from the web:
For this to hit the market: There are two drugs that have been developed by Salk Institute researchers to successfully treat Alzheimer’s in mice—and now, they have found that the very same drug compounds can also slow the aging process in the brains of healthy older mice.
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Alzheimer; News from the web:
Hmm there is some support for this but the case does not seem to be very strong.
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Alzheimer; News from the web:
The biotech world went into a full-on frenzy Tuesday when drug giant Biogen dropped this whopper: The company is reviving its Alzheimer’s drug hopeful, aducanumab, after leaving it for dead all the way back in March. In fact, it’s marching forward with a Food and Drug Administration (FDA) application to approve the drug for certain patients facing cognitive decline.
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Alzheimer; News from the web:
Alzheimer’s symptoms are diminishing due to a treatment with ultrasound to allow medicine to get through the blood-brain barrier.
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Alzheimer; News from the web:
This article from the Guardian brings us five ways to slow down Alzheimer’s onset. For details see the article in our link for today.
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