Keep this in mind, when caring for an Alzheimer’s patient

Alzheimer; News from the web:

You may not be a professional caregiver but as family of the Alzheimer’s patient you will be confronted with caring for them and interacting with them before you know it. The article in the link for today gives some important basic principles and reminders to help you through the first period.

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I want to believe this

Alzheimer; News from the web:

Novel Drug Shows Promising Results in Alzheimer’s Model

  • Scientists report that a novel small-molecule drug, which works by stopping toxic ion flow in the brain that is known to trigger neuronal apoptosis, can restore brain function and memory in a mouse model of Alzheimer’s disease (AD). The team believes the drug could be used to treat AD and other neurodegenerative diseases such as Parkinson’s and amyotropic lateral sclerosis (ALS).

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Patent law an obstacle for Alzheimer’s solutions

Alzheimer; News from the web:

You would think that all would be working cooperatively towards a solution for Alzheimer’s but this is not the case. The ridiculous costs and time that it takes to run effective tests lead to a short time to recoup your research costs when you would find a workable solution. Researchers can not make a good case that this is a wise investment for Pharmaceutical companies.

So something is really wrong here and the government should look into this.

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Leave it to Bill!

Alzheimer; News from the web:

It’s one of the holy grails of science: a cure for Alzheimer’s. Currently, there is no treatment to stop the disease, let alone slow its progression. And billionaire Bill Gates thinks he will change that.

“I believe there is a solution,” he told me without hesitation.

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Dolphins and Alzheimer’s

Alzheimer; News from the web:

Poor responses to insulin have been closely associated with Alzheimer’s disease in humans, and previous research has shown that bottlenose dolphins can also develop insulin resistance. That, combined with the recent discovery of amyloid plaques and tangled clumps of fibers in bottlenose dolphin brains, led the researchers to believe that dolphins, like us, may develop signs of Alzheimer’s disease as a result of high levels of blood sugar and insulin.

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Israeli researchers may have found a trigger!

Alzheimer; News from the web:

Dr. Debbie Toiber, of the BGU Department of Life Sciences, and her team discovered that a specific protein — Sirtuin-6 (SIRT6) — is severely reduced in the brains of Alzheimer’s patients. SIRT6 is critical to the repair of DNA, the deterioration of which “is the beginning of the chain that ends in neurodegenerative diseases in seniors,” she explains.

The blood-brain barrier prevents us from simply being able to inject the protein into the brain to replenish its supply. Dr. Toiber is currently working on finding a way to increase the expression of the protein into the brain.

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Four trials go to human phase!

Alzheimer; News from the web:

Ionis and Biogen are bringing to bear the Ionis drug technology called antisense, which targets diseases processes at the genetic level. It blocks or modifies production of proteins involved in disease.

The Phase 1/2a study of the Alzheimer’s drug, IONIS-MAPTRx, seeks evidence of safety and signs of activity. It’s to be given in 44 patients with mild Alzheimer’s over three months.The drug targets microtubule-associated tau protein, also called MATP, or tau, an abnormal protein associated with Alzheimer’s.

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Alzheimer’s is a young or middle-aged person’s disease

Alzheimer; News from the web:

“Alzheimer’s disease starts in the brain more than twenty years before the first symptom,” said Richard Isaacson, director of the Alzheimer’s Prevention Clinic at New York-Presbyterian/Weill-Cornell Medical Center. “Alzheimer’s disease is not an older person’s disease. It’s a disease of younger and middle-aged people. And that’s how we have to shift the paradigm.”

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The Alzheimer’s gene as a target!

Alzheimer; News from the web:

As a first step, a team is testing whether it’s possible to stop or slow tau-driven neuron loss and inflammation by lowering ApoE in the early life of laboratory rodents. This scheme mimics a human scenario better than the recent study, which analyzed mice that express or lack APOE from birth. “The implication here, with the recent tau findings, is that you’d really block the neurodegeneration that leads to cognitive decline,” Holtzman says.

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A new, non invasive, test for Alzheimer’s

Alzheimer; News from the web:

In the largest and most conclusive study of its kind, researchers have analysed blood samples to create a novel and non-invasive way of helping to diagnose Alzheimer’s disease and distinguishing between different types of neurodegenerative disorders.

Following this breakthrough discovery, Alzheimer’s sufferers may now have an additional test to improve the accuracy of  in order to better tailor appropriate treatment. The research also offers a valuable opportunity to monitor the .

Read all about it HERE