The Cure and the Cost

Alzheimer; News from the web:

A newly approved drug to treat Alzheimer’s disease is expected to become a multibillion-dollar expense for Medicare. By one projection, spending on the drug for Medicare’s patients could end up being higher than the budgets for the Environmental Protection Agency or NASA.

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The cost for the cure

Alzheimer; News from the web:

With the new approved drug for Alzheimer’s there is now the issue of what it will cost and how you’ll be able to afford it.

Biogen said the drug would cost approximately $56,000 for a typical year’s worth of treatment, and it said the price would not be raised for four years.

Medicare is widely expected to cover the treatment. Insurers that offer private or commercial coverage also will pay for care that doctors deem medically necessary.

That may not mean every case, though. If the treatment is proposed for a patient with advanced Alzheimer’s, and research shows the drug isn’t effective in that population, then the insurer may not pay for it.

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Finally a cure?

Alzheimer; News from the web:

A drug called aducanumab could become the first approved treatment designed to alter the course of Alzheimer’s disease rather than relieve symptoms.

But it’s unclear whether the Food and Drug Administration will approve the drug because of persistent questions about its effectiveness.

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‘Rejuvenating’ the Alzheimer’s brain

Alzheimer; News from the web:

Alzheimer’s disease is the main cause of dementia and current therapeutic strategies cannot prevent, slow down or cure the pathology. The disease is characterized by memory loss, caused by the degeneration and death of neuronal cells in several regions of the brain, including the hippocampus. Researchers have identified a small molecule that can be used to rejuvenate the brain and counteract the memory loss.

Read all about it HERE

Air quality may impact Alzheimer’s

Alzheimer; News from the web:

Researchers at the University of California, Davis, have found a link between traffic-related air pollution and an increased risk for age-related dementia, including Alzheimer’s disease. Their study, based on rodent models, corroborates previous epidemiological evidence showing this association.

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Fact Check-No evidence that Pfizer’s COVID-19 vaccine causes Alzheimer’s disease

Alzheimer; News from the web:

As of this article’s publication, the COVID-19 vaccine manufactured by Pfizer-BioNTech has not been shown to cause Prion diseases or neurodegenerative diseases such as Alzheimer’s and Lou Gehrig’s disease (ALS). Experts say a paper circulating online does not provide legitimate evidence otherwise.

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New take home drug for Alzheimer’s

Alzheimer; News from the web:

Doctors in Palm Beach County are testing a new drug that patients with mild to moderate Alzheimer’s disease can inject at home and hopefully have it repair and regenerate their brain cells.Advertisement

The clinical trial is being conducted by doctors at the Premiere Research Institute in West Palm Beach.

Read all about it HERE

Become a clinical trial volunteer

Alzheimer; News from the web:

Joe Oglesby was the highest-ranking Black newsroom executive at The Miami Herald when he announced his retirement in 2009. He and wife Linda Blash talked to us about his Alzheimer’s diagnosis and Joe’s involvement as a volunteer in an Alzheimer’s clinical trial. 

Read all about it HERE

Preventing dementia-related wandering

Alzheimer; News from the web:

The Alzheimer’s Association suggests these steps to help prevent wandering:

Have a routine for daily activities.

Identify the most likely times of day that wandering may occur. Plan activities at that time. Activities and exercise can reduce anxiety, agitation and restlessness.

Reassure the person if he or she feels lost, abandoned or disoriented. If the person with dementia wants to leave to “go home” or “go to work,” use communication focused on exploration and validation. Refrain from correcting the person. For example, “We are staying here tonight. We are safe and I’ll be with you. We can go home in the morning after a good night’s rest.”

Ensure all basic needs are met. Has the person gone to the bathroom? Is he or she thirsty or hungry?

Avoid busy places that are confusing and can cause disorientation.

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AI can help Alzheimer’s

Alzheimer; News from the web:

Have you ever wondered how Netflix knows the perfect show to recommend next? Or how Facebook suggests just the person you were looking to follow? 

Researchers have found the power of those predicting algorithms can also “predict” the biological language of cancer and neurodegenerative diseases like Alzheimer’s – which could help change completely what researchers know about treating and preventing such diseases.

Read all about it HERE

13 Alzheimer’s gene variants found

Alzheimer; News from the web:

Researchers have identified 13 variants of genes connected to Alzheimer’s disease that are new to scientists. In a study published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, the researchers report how they sequenced whole genomes of people in more than 600 families with individuals who have been diagnosed with Alzheimer’s and searched for rare versions of genes.

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Gender and Alzheimer’s

Alzheimer; News from the web:

Mounting evidence suggests that a distinction in the chemistry or structure of women’s brains may be a factor — a distinction that may lead to a sex-based difference in the appearance and aggregation of tau and beta-amyloid proteins, key biomarkers of Alzheimer’s. In a study published this month in Brainresearchers at Lund University in Sweden have found evidence that the protein tau accumulates at a higher rate in women.

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A new approach to treat Alzheimer’s disease

Alzheimer; News from the web:

A new approach to treat Alzheimer’s disease, potentially targeting the root cause of memory decline

The ACT-AD and LIFT-AD trials are evaluating if a new investigational drug is safe and effective in improving symptoms of mild to moderate Alzheimer’s disease.

The investigational drug of the ACT-AD and LIFT-AD trials is designed to:

  • Boost a repair and regenerative pathway for brain cells
  • Promote brain health and function

There may be a trial near you check it out

Read all about it HERE

Not 1 but 3 Alzheimer’s?

Alzheimer; News from the web:

What if we think of Alzheimer’s not as one disease, but three separate ones, with overlapping symptoms? Researchers behind a new study say Alzheimer’s encapsulates three distinct molecular conditions, and that a better understanding of each could be a lifeline for failed Alzheimer’s treatment efforts and future research.

Read all about it HERE

Your gut and Alzheimer’s

Alzheimer; News from the web:

The gut microbiome has been seen to affect our overall health. From our immune system, to appetite and metabolism, our gut microbiota has many influences on our health. The microbiome is composed of bacteria, archaea, viruses, and eukaryotic microbes that reside in and on our bodies. These microbes have tremendous potential to impact our physiology, both in health and in disease. Each person has an entirely unique network of microbiota that is originally determined by one’s DNA. A person is first exposed to microorganisms as an infant, and later on, environmental exposures and diet can change one’s microbiome to be either beneficial to health or place one at greater risk for disease. New research demonstrates that changes to our gut microbiome can be linked to Alzheimer’s-like behavior.

https://www.genengnews.com/

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For Alzheimer’s Patients, Racial Disparities Threaten Detection and Treatment

Alzheimer; News from the web:

Black people are about twice as likely as White people to get the disease, and Latino residents are 1.5 times more likely to suffer from it than White people. Besides their higher risks, people of color face additional Alzheimer’s challenges: noted racial disparities in how the disease is detected and how research on it is done.

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A safer Alzheimer’s drug

Alzheimer; News from the web:

In 2018, a research group led by David Holtzman, M.D., at Washington University in St. Louis developed an antibody drug in collaboration with Denali Therapeutics that showed promise as a potential Alzheimer’s disease therapy. Now, the team has returned with mouse data suggesting the drug prospect might be a safer option than Biogen’s much-hyped aducanumab.

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Alzheimer’s impact on covid-19

Alzheimer; News from the web:

Our study provides a causal link between the Alzheimer’s disease risk factor ApoE4 and COVID-19 and explains why some (e.g., ApoE4 carriers) but not all COVID-19 patients exhibit neurological manifestations. Understanding how risk factors for neurodegenerative diseases impact COVID-19 susceptibility and severity will help us to better cope with COVID-19 and its potential long-term effects in different patient populations.”

Yanhong Shi, Ph.D., Director, Division of Stem Cell Biology, City of Hope and Study’s Co-Corresponding Author

Read all about it HERE