NIH-supported research has identified a type of immune cell that helps remove waste products in the brain. Boosting these immune cells in aged mice improved the clearance of proteins associated with Alzheimer’s disease. The findings suggest potential prevention and treatment strategies for Alzheimer’s disease and related disorders.
Researchers have discovered two novel genes that increase an individual’s risk of developing Alzheimer’s disease. The researchers used a technique called exome sequencing to identify the genes. Exome sequencing is able to identify rare mutations. The discovery brings scientists closer to finding treatment options and preventative measures for the disease.
The Alzheimer’s Association is disappointed by the topline Phase 3 data reported today by Genentech and Roche from the GRADUATE Phase 3 global clinical trials of gantenerumab. However, these results will contribute to our understanding of this devastating and fatal disease. Although the drug did not meet its primary endpoint, the trials further illustrate the relationship between removal of beta-amyloid and reduction of clinical decline.
Nose-picking is a habit that is generally seen as unpleasant, but harmless. However, research from Griffith University in Queensland, Australia, suggests that the activity might not be as risk-free as previously thought.
The rePair Sleep Study is researching the use of a cognitive behavioral interventional plan that is used to improve sleep quality for both caregivers and persons living with cognitive impairment. The intervention involves discussions centered on sleep and adjustment of sleep habits. The intervention will take place via videoconferencing for 7 online visits where participants will complete questionnaires, daily sleep diaries, and wear a watch to monitor their activity.
Emory University researchers are looking for:
Persons with cognitive impairment who:Have a reported diagnosis of cognitive impairmentCo-reside with their caregiverHave sleep disturbancesCan read, speak and understand English Are willing to wear a wristwatch for 4 weeksAnd their caregiver who:Is an informal caregiver of co-residing person living with cognitive impairmentProvides unpaid caregiving assistance on average of 20 hours/week to person living with cognitive impairmentHas sleep disturbancesCan read, speak and understand EnglishIs willing to wear a wristwatch for 4 weeksThe caregiver and the person living with cognitive impairment will each receive a $25 gift card after completing the baseline visit, a $50 gift card after the completing the first post-intervention visit, and $25 after completing the 3-month post-intervention visit.
The number of Americans living with Alzheimer’s continues to rise. Currently, an estimated 6.5 million Americans age 65 and older are living with Alzheimer’s — about 1 in 9. By 2050, the number is projected to reach nearly 13 million.
This and more facts and figures in the annual report from the Alzheimer’s association.
The purpose of the Brain Health Registry is to speed up the discovery of treatments for Alzheimer’s disease and other brain disorders. Joining the Brain Health Registry is easy. Participation takes less than three hours per year and can be completed entirely online.
If you choose to participate, you will be required to agree to a consent form. Once you give your consent, you will complete some questionnaires about your medical history, current health and lifestyle and take some online memory and thinking tests. You will be asked to come back every 6 months to answer more questions and take more tests. You may also have the opportunity to participate in additional research studies.
Brain Health Registry researchers are looking for people who are:
18 years and older
Healthy volunteers, as well as those who have been diagnosed with Mild Cognitive Impairment, Alzheimer’s disease, or dementia
Alzheimer’s is a progressive neurodegenerative disorder, and the risk of developing it doubles every 5 years after an individual turns 65 years old. It is characterized by a continuous decline in completion of familiar tasks, memory loss, and thinking. Risk factors include aging, brain trauma, diabetes, family history, high blood pressure, and smoking.
For people living with Alzheimer’s and their caregivers, the abrupt weather swings we experience pose special challenges. Caregivers need to watch for signs of cold such as pale skin, acting sleepy, cold feet or hands or shivering, and make sure the person is dressed warmly in layers while inside. Monitor indoor temperatures, and act accordingly.
Brain health is one of the hottest topics in the medical world, and for good reason: As more of the population ages, more people are developing dementia, a category of progressive brain disorders that includes Alzheimer’s disease. Neurosurgeon and CNN chief medical correspondent Dr. Sanjay Gupta is on a personal mission to promote brain health—as he writes in the book Keep Sharp, his grandfather died from Alzheimer’s disease—and he has isolated five science-backed ways to reduce your risk of the same fate.
A new blood test may identify more than 80% of people with increased likelihood of having amyloid in the brain, a protein that’s a risk factor for developing Alzheimer’s disease, according to a recent study that was presented this week at Boston’s international Clinical Trials on Alzheimer’s Disease conference.
WASHINGTON — Medicare’s “Part B” outpatient premium will jump by $21.60 a month in 2022, one of the largest increases ever. Officials said Friday a new Alzheimer’s drug is responsible for about half of that.
Past research, mainly performed on animals, suggested the aggregates form in one region then spread throughout the brain, much like how cancer spreads.
The new study suggests that while such spread may occur, it’s not in fact the main driver of disease progression.
“Once we have these seeds, little bits of aggregate throughout the brain, they just multiply and that process controls the speed,” said Meisl.
An analogy from the COVID pandemic is how travel bans between nations generally proved ineffective at stopping the spread of the virus, because it was already replicating within the countries trying to keep it out.
The team was also able to determine the time it takes the aggregates to double in number — roughly five years. That is an “encouraging” figure, said Meisl, because it shows the brain’s neurons already are good at countering aggregates.
“Maybe if we can make it just a tiny bit better we can significantly delay the onset of serious disease.”
The Alzheimer’s Foundation of America (AFA) is providing information to dispel common falsehoods about Alzheimer’s disease to help individuals know the warning signs, understand the importance of early detection, and learn how to be proactive about reducing their risk.
“Dispelling the misconceptions about Alzheimer’s disease is critically important, because they may cause people to ignore symptoms and delay taking action which impacts their health and quality of life,” said Charles J. Fuschillo, Jr., AFA’s President & CEO. “National Alzheimer’s Awareness Month is the perfect time to reinforce factual information that can help someone spot the warning signs, get screened, and be proactive about their brain health.”
A small village in Dax, France, is working to find a better way to handle the increasing caseload. In one of the first research projects of its kind, the small town houses around 110 people with early- to late-stage Alzheimer’s who are free to roam and visit the village’s supermarket, hairdresser, restaurant, café, library, and music hall. With a daily cost of €65 ($75), the program aims to allow people to exist with greater autonomy, purpose, and freedom without facing immediate financial hardship. “If it is not for everyone, it doesn’t work,” said Mathilde Charon-Burnel, a spokesperson for the experiment.