New phase in a promising trial

Alzheimer; News from the web:

Alzamend Neuro has dosed the first patient in the multiple ascending dose portion of its Phase 2a clinical trial of AL001, an investigational oral therapy for dementia related to Alzheimer’s disease.

This multiple ascending dose (MAD) part follows positive results from a Phase 1 trial. Topline data from the Phase 2a trial is expected in December.

Read all about it HERE

You may be able to help Alzheimer’s research

Alzheimer; News from the web:

Now Enrolling: Sleep Intervention Study for Dementia Caregiving Pairs (The rePair Sleep Study) – OnlineEmory University researchers invite you to participate in Sleep Intervention Study for Dementia Caregiving Pairs (The rePair Sleep Study) a study to determine if cognitive behavioral therapy for insomnia is a practical and useful intervention for sleep problems. 

The rePair Sleep Study is researching the use of a cognitive behavioral interventional plan that is used to improve sleep quality for both caregivers and persons living with cognitive impairment. The intervention involves discussions centered on sleep and adjustment of sleep habits. The intervention will take place via videoconferencing for 7 online visits where participants will complete questionnaires, daily sleep diaries, and wear a watch to monitor their activity. 

Emory University researchers are looking for:

Persons with cognitive impairment who:Have a reported diagnosis of cognitive impairmentCo-reside with their caregiverHave sleep disturbancesCan read, speak and understand English Are willing to wear a wristwatch for 4 weeksAnd their caregiver who:Is an informal caregiver of co-residing person living with cognitive impairmentProvides unpaid caregiving assistance on average of 20 hours/week to person living with cognitive impairmentHas sleep disturbancesCan read, speak and understand EnglishIs willing to wear a wristwatch for 4 weeksThe caregiver and the person living with cognitive impairment will each receive a $25 gift card after completing the baseline visit, a $50 gift card after the completing the first post-intervention visit, and $25 after completing the 3-month post-intervention visit.

 For a full description of The rePair Sleep Study, please visit our website.
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Facts and figures about Alzheimer’s for 2022

Alzheimer; News from the web:

The number of Americans living with Alzheimer’s continues to rise. Currently, an estimated 6.5 million Americans age 65 and older are living with Alzheimer’s — about 1 in 9. By 2050, the number is projected to reach nearly 13 million.

This and more facts and figures in the annual report from the Alzheimer’s association.

Read all about it HERE

Outcomes of the Alzheimer’s research conference

Alzheimer; News from the web:

Alzheimer’s Research UK’s annual conference showcased the latest dementia research findings and allowed face-to-face collaboration for the first time since the COVID-19 pandemic.

600 of our inspirational dementia researchers, all at different points in their careers, shared the work they have been doing over the past few years. Here are some of the highlights!

Read all about it HERE

The importance of your sleep

Alzheimer; News from the web:

The brain’s ability to clear a protein closely linked to Alzheimer’s disease is tied to our circadian cycle, according to research published last week in PLOS Genetics.

The research underscores the importance of healthy sleep habits in preventing the protein Amyloid-Beta 42 from forming clumps in the brain, and opens a path to potential Alzheimer’s therapies.

Read all about it HERE

Alzheimer prevention registry

Alzheimer; News from the web:

The Alzheimer prevention registry sent us this:

Now Enrolling: The Brain Health Registry – Online

The purpose of the Brain Health Registry is to speed up the discovery of treatments for Alzheimer’s disease and other brain disorders. Joining the Brain Health Registry is easy. Participation takes less than three hours per year and can be completed entirely online.

If you choose to participate, you will be required to agree to a consent form. Once you give your consent, you will complete some questionnaires about your medical history, current health and lifestyle and take some online memory and thinking tests. You will be asked to come back every 6 months to answer more questions and take more tests. You may also have the opportunity to participate in additional research studies.

Brain Health Registry researchers are looking for people who are:

  • 18 years and older
  • Healthy volunteers, as well as those who have been diagnosed with Mild Cognitive Impairment, Alzheimer’s disease, or dementia

For a full description of the Brain Health Registry, please visit our website.

Early identification is key for Alzheimer’s

Alzheimer; News from the web:

Alzheimer’s is a progressive neurodegenerative disorder, and the risk of developing it doubles every 5 years after an individual turns 65 years old. It is characterized by a continuous decline in completion of familiar tasks, memory loss, and thinking. Risk factors include aging, brain trauma, diabetes, family history, high blood pressure, and smoking.

Read all about it HERE

Weather swings not good for people with Alzheimer’s

Alzheimer; News from the web:

For people living with Alzheimer’s and their caregivers, the abrupt weather swings we experience pose special challenges. Caregivers need to watch for signs of cold such as pale skin, acting sleepy, cold feet or hands or shivering, and make sure the person is dressed warmly in layers while inside. Monitor indoor temperatures, and act accordingly.

Read all about it HERE

Protect yourself against Alzheimer’s these 5 ways

Alzheimer; News from the web:

Brain health is one of the hottest topics in the medical world, and for good reason: As more of the population ages, more people are developing dementia, a category of progressive brain disorders that includes Alzheimer’s disease. Neurosurgeon and CNN chief medical correspondent Dr. Sanjay Gupta is on a personal mission to promote brain health—as he writes in the book Keep Sharp, his grandfather died from Alzheimer’s disease—and he has isolated five science-backed ways to reduce your risk of the same fate.

Read all about it HERE

Will drinking coffee protect us from Alzheimer’s?

Alzheimer; News from the web:

  • There is currently no cure for Alzheimer’s disease, although treatment and lifestyle changes can slow its progression.
  • A new Australian study suggests that higher coffee intake might be linked to a slower rate of cognitive decline.
  • There was also an association between higher coffee intake and slower accumulation of amyloid deposits in the brain.

Read all about it HERE

Blood test for Alzheimer’s

Alzheimer; News from the web:

A new blood test may identify more than 80% of people with increased likelihood of having amyloid in the brain, a protein that’s a risk factor for developing Alzheimer’s disease, according to a recent study that was presented this week at Boston’s international Clinical Trials on Alzheimer’s Disease conference.

Read all about it HERE

New research details how Alzheimer’s starts

Alzheimer; News from the web:

Past research, mainly performed on animals, suggested the aggregates form in one region then spread throughout the brain, much like how cancer spreads.

The new study suggests that while such spread may occur, it’s not in fact the main driver of disease progression.

“Once we have these seeds, little bits of aggregate throughout the brain, they just multiply and that process controls the speed,” said Meisl.

An analogy from the COVID pandemic is how travel bans between nations generally proved ineffective at stopping the spread of the virus, because it was already replicating within the countries trying to keep it out.

The team was also able to determine the time it takes the aggregates to double in number — roughly five years. That is an “encouraging” figure, said Meisl, because it shows the brain’s neurons already are good at countering aggregates. 

“Maybe if we can make it just a tiny bit better we can significantly delay the onset of serious disease.”

Read all about it HERE

Five Common Falsehoods About Alzheimer’s Disease

Alzheimer; News from the web:

The Alzheimer’s Foundation of America (AFA) is providing information to dispel common falsehoods about Alzheimer’s disease to help individuals know the warning signs, understand the importance of early detection, and learn how to be proactive about reducing their risk.

“Dispelling the misconceptions about Alzheimer’s disease is critically important, because they may cause people to ignore symptoms and delay taking action which impacts their health and quality of life,” said Charles J. Fuschillo, Jr., AFA’s President & CEO. “National Alzheimer’s Awareness Month is the perfect time to reinforce factual information that can help someone spot the warning signs, get screened, and be proactive about their brain health.”

Read all about it HERE

How about Alzheimer’s villages?

Alzheimer; News from the web:

A small village in Dax, France, is working to find a better way to handle the increasing caseload. In one of the first research projects of its kind, the small town houses around 110 people with early- to late-stage Alzheimer’s who are free to roam and visit the village’s supermarket, hairdresser, restaurant, café, library, and music hall. With a daily cost of €65 ($75), the program aims to allow people to exist with greater autonomy, purpose, and freedom without facing immediate financial hardship. “If it is not for everyone, it doesn’t work,” said Mathilde Charon-Burnel, a spokesperson for the experiment.

Read all about it HERE

Alzheimer’s and Covid; a connection found

Alzheimer; News from the web:

Researchers have identified a genetic link between Alzheimer’s and severe cases of COVID-19 that may open new avenues into the treatment of both diseases.

The study, published in the journal Brain , found that the presence of a variant of the OAS1 gene increases the risk of developing Alzheimer’s disease by three to six per cent, while similar variants of the same gene increase the odds of contracting a case of severe COVID. In addition to presenting new possibilities for treatment, researchers hope this overlap may shed light on other infectious diseases and dementias.

Read all about it HERE

Alzheimer’s therapy for people with Down syndrome

Alzheimer; News from the web:

Researchers at the University of Colorado School of Medicine have been awarded a $4.6 million, five-year grant by the National Institute on Aging to study whether a potential Alzheimer’s disease treatment is safe and effective in improving cognitive function in young adults with Down syndrome.

Huntington Potter, PhD, professor of neurology, and Peter Pressman, MD, assistant professor of neurology, are principal investigators on the study of sargramostim, which is also know by the brand name Leukine, an FDA-approved drug with nearly 30 years of safe use in numerous patient populations.

“This is the first clinical trial in years to target cognition in people with Down syndrome,” said Potter, who is director of University of Colorado Alzheimer’s and Cognition Center. “We are breaking new ground in studying both of these disorders – Down syndrome and Alzheimer’s disease. We hope that this therapy will greatly improve their quality of life.”

Read all about it HERE

The importance of sleep in a new study

Alzheimer; News from the web:

Disrupted sleep is common in late life, the study authors wrote, and associated with changes in cognitive function — the mental capacity for learning, thinking, reasoning, problem-solving, decision-making, remembering and paying attention.Age-related changes in sleep have also been linked with early signs of Alzheimer’s disease, depression and cardiovascular disease, so the authors investigated possible associations between self-reported sleep duration, demographic and lifestyle factors, subjective and objective cognitive function, and participants’ levels of beta amyloid.

Read all about it HERE

Yoga for Alzheimer’s

Alzheimer; News from the web:

According to a US study published on Brain Plasticity, “Compared to traditional forms of aerobic and anaerobic exercise, the relatively low-impact, modifiable nature of yoga can offer a middle ground for individuals with movement limitations, clinical diagnoses, and is particularly suitable for aging populations. Yoga’s focus on improving the self through both physical and mental practices incorporates more mindful elements absent in traditional forms of exercise.”

Read all about it HERE