The 2026 Alzheimer disease drug development landscape highlights a growing shift toward diverse disease-modifying strategies, from amyloid and tau targeting to metabolic and neuroprotective approaches.
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Category Archives: Alzheimer Overview
Rethinking Alzheimer’s clinical trials to include atypical forms of the disease
A paper published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association examines the limitations of current clinical trials in Alzheimer’s disease and proposes ways to better adapt them to the clinical diversity of the condition.
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Associations of stable psychological traits with multi-omic subtypes of Alzheimer’s dementia
Psychological traits reflecting neuroticism, depressive symptoms, loneliness, and purpose in life are risk factors of AD dementia; however, the underlying biological mechanisms remain largely unknown. Using multi-omic data from the dorsolateral prefrontal cortex of 822 decedents in the Religious Orders Study and Rush Memory and Aging Project, we utilized a previously derived multi-omic brain molecular pseudotime representing molecular distance from no cognitive impairment (NCI) to AD dementia, and three distinct multi-omic brain molecular subtypes of AD dementia.
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Is hearing loss an Alzheimer’s warning sign? Research shows new risk factors
One clear risk factor, the research shows, is hearing loss.
“We know from a lot of public health studies that hearing loss changes the brain, and we have also seen in studies that hearing loss is consistently linked to a higher risk of dementia over time,” said Jennifer Deal, an associate professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health, in a recent media briefing on Alzheimer’s.
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A common stomach infection may be increasing the risk of Alzheimer’s disease
reliminary research suggests there may be an association between H. pylori and dementia. [1] MDLinx spoke with three experts who say while the research is interesting, there is not enough definitive evidence at this stage to change clinical practice.
The jury is still out on this one since the studies are not of the highest quality and results are not consistent, according to Julie Parsonnet, MD, an infectious diseases clinician and epidemiologist at Stanford University. Some studies show an association, she says, and others do not.
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Dougherty County Alzheimer’s rate among highest in America
Dougherty County has the highest rate of Alzheimer’s disease of any county in Georgia and the seventh highest in the United States, according to data from the Alzheimer’s Association.
Fifteen percent of people living in Dougherty County have Alzheimer’s, health experts said.
“So fifteen percent, of course, is quite high, especially being that our patient population, there are a lot of elderly patients,” said Dr. Dominique Mortel, a neurologist at Phoebe. “So we tend to see a lot of patients come here to our neurology clinic concerned about memory issues, especially with fifteen percent of the Dougherty County population being affected.”
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