Compound Produced by Gut Bacteria May Slow Alzheimer’s Progression

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A compound found in the gut may reduce some of the manifestations of Alzheimer’s disease, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

While mounting evidence has pointed to a connection between the gut microbiome and the degenerative effects of Alzheimer’s disease, the mechanisms are not well understood, said Robert Vassar, PhD, the Davee Professor of Alzheimer Research and professor of Neurology and director of the Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, who was senior author of the study.

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University of California San Diego Researchers Develop Gene Therapy Targeting Brain Cell Mechanisms in Alzheimer’s Disease

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Researchers at the University of California San Diego School of Medicine have developed a gene therapy for Alzheimer’s disease that aims to protect the brain from damage and preserve cognitive function. This approach differs from existing treatments, which primarily target unhealthy protein deposits in the brain. Instead, the new therapy focuses on addressing the root cause of Alzheimer’s by influencing how brain cells behave.

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FDA Approves First Blood Test for Alzheimer’s Disease

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Now doctors have a new tool: an Alzheimer’s blood test. The Food and Drug Administration recently approved the first test that uses a blood sample to help diagnose Alzheimer’s disease. The disease, which causes a decline in memory and thinking skills, affects nearly 7 million Americans—and is projected to become more prevalent.

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Alzheimer’s disease affects an organism as a whole

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While Alzheimer’s disease is mostly considered a disorder of the brain, emerging evidence suggests that the condition also affects other organs of the body. Working with the laboratory fruit fly, researchers at Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital (Duncan NRI) and collaborating institutions provide a new understanding of how Alzheimer’s disease affects different tissues across the entire body.

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Can nasal spray keep Alzheimer’s at bay?

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The experimental treatment is part of a larger effort to find new ways to interrupt the cascade of events in the brain that lead to Alzheimer’s dementia.

Two drugs now on the market clear the brain of sticky amyloid plaques, clumps of toxic protein that accumulate between neurons. Other experimental drugs have targeted the tau tangles, a different protein that builds up inside nerve cells.

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