Alzheimer; News from the web:
Levels of lithium were significantly reduced in the prefrontal cortex of people with mild cognitive impairment and Alzheimer’s disease (AD).
In a mouse model of AD, a low-dose lithium salt in the diet reversed memory loss and prevented cognitive decline in aging mice.
While more study is needed, lithium replacement could be a potential approach to prevent and treat AD.
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Alzheimer; News from the web:
Middle-aged men and women who opted to cycle or walk had a lower risk of developing dementia years later than their peers who rode in a car or took a bus, according to a new report.
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Alzheimer; News from the web:
There is no cure for Alzheimer’s disease, but medication can help manage the condition. Currently, the main drugs used to treat Alzheimer’s are what’s known as symptomatic therapies, meaning they ease symptoms but don’t address the cause of the disease. These include cholinesterase inhibitors and memantine. A more recent entry into the field, lecanemab, may help slow the progression of the disease. Here’s a look at how these medications work.
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Alzheimer; News from the web:
A groundbreaking study suggests that the immune molecule STING may play a critical role in Alzheimer’s and other neurodegenerative diseases by exacerbating brain inflammation and damage. Blocking STING in lab models protected against cognitive decline, opening a promising new path for therapeutic development.
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Alzheimer; News from the web:
Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer’s disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise. These findings, which were validated in samples from people, shed light on the connection between exercise and brain health and point to future drug targets. Results are published in Nature Neuroscience.
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Alzheimer; News from the web:
Alzheimer’s disease develops slowly and silently, with biological changes in the brain beginning many years before any symptoms appear. A new study from researchers at the UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND) shows that we may be able to identify those most at risk using two simple and widely accessible tools: a blood test and a brief unsupervised memory assessment.
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