Researchers in the department of genetics at the Yale School of Medicine have developed a technique that allows them to construct 3D brain organoids to better study Alzheimer’s disease.
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Category Archives: Research
Groundbreaking study shows Alzheimer’s may be reversible in advanced stages
Cleveland researchers achieve full cognitive recovery in mice, offering new hope for dementia patients.
Dr. Andrew Pieper, director of the Brain Health Medicines Center at University Hospitals and senior author of the study, emphasizes this represents a fundamental shift in understanding the disease. “The key takeaway is a message of hope – the effects of Alzheimer’s disease may not be inevitably permanent,” Pieper explained. “The damaged brain can, under some conditions, repair itself and regain function.”
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Alzheimer’s Might Not Actually Be a Brain Disease, Reveals Expert
Based on our past 30 years of research, we no longer think of Alzheimer’s as primarily a disease of the brain. Rather, we believe that Alzheimer’s is principally a disorder of the immune system within the brain.
The immune system, found in every organ in the body, is a collection of cells and molecules that work in harmony to help repair injuries and protect from foreign invaders.
When a person trips and falls, the immune system helps to mend the damaged tissues. When someone experiences a viral or bacterial infection, the immune system helps in the fight against these microbial invaders.
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Alzheimer’s reversible? Regulating molecule in brain is key, doctor says
Alzheimer’s may be reversible if levels of a molecule known as NAD+ can be regulated in the brain, according to a researcher who helped test the approach in mice.
In a study published last month, scientists said they were able to use pharmacology to reverse advanced Alzheimer’s in mice that had been genetically programmed to develop the disease.
Researchers said they achieved this by stabilizing the levels of NAD+ (nicotinamide adenine dinucleotide) — an energy-producing chemical that is low in human Alzheimer’s patients — within the brains of lab animals.
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Increased Levels of a Protein Linked to Alzheimer’s Found in Some With Long COVID
A study of 227 individuals who experienced neuro cognitive difficulties post COVID-19 infection – such as headaches, vertigo, balance dysregulation, changes in taste/smell, and brain fog – displayed a significant increase in their blood plasma of a crucial protein called tau, which is found in nerves and especially in the brain. Excess levels of tau are linked to neurodegenerative diseases and found in many Alzheimer’s patients.
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What Our Body Clocks May Say About Our Alzheimer’s Risk
Our circadian rhythms, the internal body clock that determines when we are most active and alert and when we wind down and go to sleep during a typical 24-hour day, may play a role in our risk of dementia, according to a new report. The study found that people with less regular circadian rhythms, as well as those whose activity levels peaked later in the afternoon, were at increased risk of developing Alzheimer’s disease and other forms of dementia.
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