Indiana University School of Medicine scientists have identified a promising drug target for Alzheimer’s disease. The team found that removing an enzyme from neurons in the brain substantially reduces amyloid plaques—a hallmark characteristic of the disease—and may provide further resilience against disease progression.
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Patients with dementia who participated in a Medicare-funded collaborative care program that provided support and medical advice for caregivers were able to remain in their home communities longer before entering nursing homes, according to a new study. This compares to those patients who were taking lecanemab, one of two approved drugs that have been shown to slow progression of Alzheimer’s in some patients, a February study published in Alzheimer’s & Dementia: Behavior & Socioeconomics of Aging found.
In a new study that could have significant implications for future Alzheimer’s treatment, researchers at the University of Miami have successfully figured out how to combat one of the early signs of the neurodegenerative disease.
In the study published in the Journal of the Alzheimer’s Association in December 2025 — “Systemic Piezo1 activation improves cerebrovascular function in Alzheimer’s disease“
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According to the National Institute on Aging, the Alzheimer’s Association, and other researchers, Black Americans are approximately twice as likely as white Americans to develop dementia and Alzheimer’s. The reasons for this disparity are unknown — perhaps in part because Black individuals are much less likely than whites to participate in Alzheimer’s and dementia research studies.
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New findings reveal a subtle but powerful breakdown that may help explain early memory loss in Alzheimer’s.
When the brain rests, it usually replays recent experiences to strengthen memory. Scientists found that in Alzheimer’s-like mice, this replay still occurs — but the signals are jumbled and poorly coordinated. As a result, memory-supporting brain cells lose their stability, and the animals struggle to remember where they’ve been.
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