Potential new treatment for Alzheimer’s disease, other neurodegenerative conditions

Investigators at Case Western Reserve UniversityUniversity Hospitals and the Louis Stokes Cleveland VA Medical Center have identified a new and promising drug to treat AD.

The drug—and their approach by identifying a new target in the brain—showed promising results in mouse models of AD. Their findings were reported in a study published May 21 in the scientific journal Proceedings of the National Academy of Sciences (PNAS).

“Our findings suggest an effective new way to safely prevent neurodegeneration and cognitive impairment in Alzheimer’s disease by directly protecting the blood-brain barrier (BBB),” said the study’s co-lead researcher Andrew Pieper, a psychiatrist and neuroscientist, the Case Western Reserve University Rebecca E. Barchas MD DLFAPA University Professor of Translational Psychiatry and the Morley-Mather Chair of Neuropsychiatry at University Hospitals Cleveland Medical Center.

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Clearing waste products in the brain may get easier

Alzheimer; News from the web:

NIH-supported research has identified a type of immune cell that helps remove waste products in the brain. Boosting these immune cells in aged mice improved the clearance of proteins associated with Alzheimer’s disease. The findings suggest potential prevention and treatment strategies for Alzheimer’s disease and related disorders.

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Protect yourself against Alzheimer’s these 5 ways

Alzheimer; News from the web:

Brain health is one of the hottest topics in the medical world, and for good reason: As more of the population ages, more people are developing dementia, a category of progressive brain disorders that includes Alzheimer’s disease. Neurosurgeon and CNN chief medical correspondent Dr. Sanjay Gupta is on a personal mission to promote brain health—as he writes in the book Keep Sharp, his grandfather died from Alzheimer’s disease—and he has isolated five science-backed ways to reduce your risk of the same fate.

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Will drinking coffee protect us from Alzheimer’s?

Alzheimer; News from the web:

  • There is currently no cure for Alzheimer’s disease, although treatment and lifestyle changes can slow its progression.
  • A new Australian study suggests that higher coffee intake might be linked to a slower rate of cognitive decline.
  • There was also an association between higher coffee intake and slower accumulation of amyloid deposits in the brain.

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The importance of sleep in a new study

Alzheimer; News from the web:

Disrupted sleep is common in late life, the study authors wrote, and associated with changes in cognitive function — the mental capacity for learning, thinking, reasoning, problem-solving, decision-making, remembering and paying attention.Age-related changes in sleep have also been linked with early signs of Alzheimer’s disease, depression and cardiovascular disease, so the authors investigated possible associations between self-reported sleep duration, demographic and lifestyle factors, subjective and objective cognitive function, and participants’ levels of beta amyloid.

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