Category Archives: Treatment

Groundbreaking study shows Alzheimer’s may be reversible in advanced stages

Posted on by

Cleveland researchers achieve full cognitive recovery in mice, offering new hope for dementia patients.

Dr. Andrew Pieper, director of the Brain Health Medicines Center at University Hospitals and senior author of the study, emphasizes this represents a fundamental shift in understanding the disease. “The key takeaway is a message of hope – the effects of Alzheimer’s disease may not be inevitably permanent,” Pieper explained. “The damaged brain can, under some conditions, repair itself and regain function.”

See the full article HERE

Alzheimer’s Might Not Actually Be a Brain Disease, Reveals Expert

Posted on by

Based on our past 30 years of research, we no longer think of Alzheimer’s as primarily a disease of the brain. Rather, we believe that Alzheimer’s is principally a disorder of the immune system within the brain.

The immune system, found in every organ in the body, is a collection of cells and molecules that work in harmony to help repair injuries and protect from foreign invaders.

When a person trips and falls, the immune system helps to mend the damaged tissues. When someone experiences a viral or bacterial infection, the immune system helps in the fight against these microbial invaders.

See the original article HERE

Alzheimer’s reversible? Regulating molecule in brain is key, doctor says

Posted on by

Alzheimer’s may be reversible if levels of a molecule known as NAD+ can be regulated in the brain, according to a researcher who helped test the approach in mice.

In a study published last month, scientists said they were able to use pharmacology to reverse advanced Alzheimer’s in mice that had been genetically programmed to develop the disease.

Researchers said they achieved this by stabilizing the levels of NAD+ (nicotinamide adenine dinucleotide) — an energy-producing chemical that is low in human Alzheimer’s patients — within the brains of lab animals.

Read the original post HERE

Drugs for Alzheimer’s disease

Posted on by

Alzheimer; News from the web:

There is no cure for Alzheimer’s disease, but medication can help manage the condition. Currently, the main drugs used to treat Alzheimer’s are what’s known as symptomatic therapies, meaning they ease symptoms but don’t address the cause of the disease. These include cholinesterase inhibitors and memantine. A more recent entry into the field, lecanemab, may help slow the progression of the disease. Here’s a look at how these medications work.

Read all about it HERE

Exercise targets specific brain cells to protect against Alzheimer’s

Posted on by

Alzheimer; News from the web:

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer’s disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise. These findings, which were validated in samples from people, shed light on the connection between exercise and brain health and point to future drug targets. Results are published in Nature Neuroscience. 

Read all about it HERE

Compound Produced by Gut Bacteria May Slow Alzheimer’s Progression

Posted on by

Alzheimer; News from the web:

A compound found in the gut may reduce some of the manifestations of Alzheimer’s disease, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

While mounting evidence has pointed to a connection between the gut microbiome and the degenerative effects of Alzheimer’s disease, the mechanisms are not well understood, said Robert Vassar, PhD, the Davee Professor of Alzheimer Research and professor of Neurology and director of the Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, who was senior author of the study.

Read all about it HERE