Category Archives: Research

Scientists Discover Brain-Penetrating Compounds That May Calm Alzheimer’s-Linked Inflammation

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Researchers have created a targeted compound that blocks an enzyme linked to inflammation in individuals with a genetic predisposition to Alzheimer’s disease, while still maintaining normal brain activity and successfully passing through the blood-brain barrier.

Scientists at the University of Southern California report that they have found new druglike compounds that could calm a major source of brain inflammation tied to Alzheimer’s disease. The study was just published in the Nature journal npj Drug Discovery.

Read all about it HERE

Alzheimer’s may trick the brain into erasing its own memories

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Alzheimer’s may destroy memory by flipping a single molecular switch that tells neurons to prune their own connections. Researchers found that both amyloid beta and inflammation converge on the same receptor, triggering synapse loss. Surprisingly, neurons aren’t passive victims—they actively respond to these signals. Targeting this receptor could offer a new way to protect memory beyond current amyloid-focused drugs.

Read more about this HERE

Why Alzheimer’s Patients Lose New Memories First

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Some loved ones may struggle to recall what they ate for lunch just an hour ago, yet they can vividly describe a childhood vacation from fifty years ago. For many families navigating an Alzheimer’s diagnosis, this is one of the most perplexing symptoms — the loss of short-term memory vs. long-term recollection.

However, this selective memory loss is not random. According to G. Peter Gliebus, M.D., chief of neurology and director of Cognitive and Behavioral Neurology at Marcus Neuroscience Institute, part of Baptist Health, at Boca Raton Regional Hospital, there is a specific biological reason why the brain’s timeline seems to unravel from the present backward.

Read all about it HERE

Groundbreaking study shows Alzheimer’s may be reversible in advanced stages

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Cleveland researchers achieve full cognitive recovery in mice, offering new hope for dementia patients.

Dr. Andrew Pieper, director of the Brain Health Medicines Center at University Hospitals and senior author of the study, emphasizes this represents a fundamental shift in understanding the disease. “The key takeaway is a message of hope – the effects of Alzheimer’s disease may not be inevitably permanent,” Pieper explained. “The damaged brain can, under some conditions, repair itself and regain function.”

See the full article HERE

Alzheimer’s Might Not Actually Be a Brain Disease, Reveals Expert

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Based on our past 30 years of research, we no longer think of Alzheimer’s as primarily a disease of the brain. Rather, we believe that Alzheimer’s is principally a disorder of the immune system within the brain.

The immune system, found in every organ in the body, is a collection of cells and molecules that work in harmony to help repair injuries and protect from foreign invaders.

When a person trips and falls, the immune system helps to mend the damaged tissues. When someone experiences a viral or bacterial infection, the immune system helps in the fight against these microbial invaders.

See the original article HERE