Category Archives: Research

New Gene Thought to Be Cause in Early-Onset Forms of Alzheimer’s Disease

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A new gene that causes early-onset of Alzheimer’s disease has been discovered by the research team of Dominique Campion at the Insert unit 1079 “Genetics of cancer and neuropsychiatric diseases” in Rouen. The research scientists showed that in the families of 5 of 14 patients suffering from the disease, mutations were detected on the gene SORL1. This gene regulates the production of a peptide involved in Alzheimer’s disease.

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Alzheimer’s and brain deposits: Researchers study connections

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With recent studies focusing more attention on memory loss, there is concern among Baby Boomers. However, some hopeful news has been emerging on the important topic of brain amyloid (protein deposits).ScienceDaily (Mar. 30, 2012) noted in reporting about amyloid beta in the brain of individuals with Alzheimer’s disease that although “there may not be a consensus as to whether the deposition contributes to the disease or is a consequence of the disease, there is agreement that it is not favored thermodynamically, meaning that something else is promoting the process.”Amyloid beta in the brain of individuals with Alzheimer’s disease

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Antibiotics for Alzheimer’s?

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Researchers believe they have gained key insights on the development and progression of Alzheimer’s disease.

The findings could lead to the development of antibiotic treatments that could prevent the onset of the devastating illness.

Investigators have learned that a key protein, called a tau-protein, transforms from being a critical component of normal brain function to a sinister malformed villain that destroys brain cells.

Researchers at Beth Israel Deaconess Medical Center (BIDMC) developed the technology that distinguishes the two tau isoforms — one healthy and one disease-causing. Their research shows that only the disease-causing isoform is found in the neurons of Alzheimer’s patients and is exhibited at a very early stage of disease.

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Vascular Dementia and Alzheimer’s Disease: Need to Study these Brain Illnesses

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Following Alzheimer’s disease, Vascular dementia is another common cause of dementia. It is hard to believe for any individual that he is suffering from such a disease which makes him forget even his own home and family. In UK, around 200,000 people are affected by this disease. But experts still have to find out the reason behind the occurrence of this illness. The origins of vascular dementia are still unknown to them.

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Treating Alzheimer’s Disease: A Role for the FKBP52 Protein

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New research in humans reveals that the so-called FKBP52 protein may prevent the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer’s drugs and for detecting the disease before the onset of clinical symptoms.

A study published online March 21 in the Journal of Alzheimer’s Disease, for the first time demonstrates that the FKBP52 protein, discovered by Prof. Etienne BAULIEU twenty years ago, may prevent hyperphosphorylation of Tau protein, which has been shown to characterise a number of cerebral neurodegenerative diseases, including Alzheimer’s Disease (AD).

This work has been carried out by Professor Etienne Baulieu and his research team at Inserm (National Institute for medical research in France) with the support of philanthropists who help the Institut Baulieu, based in France.

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Antioxidant supplements ineffective against Alzheimer’s, study shows

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For years, doctors have touted an antioxidant-rich diet to help stave off memory loss and dementia. A new study says antioxidants may not do much for preventing Alzheimer’s after all.

An antioxidant cocktail of vitamin E, vitamin C, and lipoic acid had no effect on reducing the physical signs and cognitive decline seen in Alzheimer’s disease, the study found.

Antioxidants are found in apples, blueberries, cranberries, pomegranates, strawberries and other types of fruit. Earlier research suggests a diet rich in antioxidants boosts memory and prevent age-related memory loss. They’re thought to work by protecting cells against free radicals, which are single molecules that latch onto a cell and cause damage. Antioxidants are also thought to have a protective benefit against cancer and heart disease.

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