Category Archives: Research

Vascular Dementia and Alzheimer’s Disease: Need to Study these Brain Illnesses

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Following Alzheimer’s disease, Vascular dementia is another common cause of dementia. It is hard to believe for any individual that he is suffering from such a disease which makes him forget even his own home and family. In UK, around 200,000 people are affected by this disease. But experts still have to find out the reason behind the occurrence of this illness. The origins of vascular dementia are still unknown to them.

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Treating Alzheimer’s Disease: A Role for the FKBP52 Protein

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New research in humans reveals that the so-called FKBP52 protein may prevent the Tau protein from turning pathogenic. This may prove significant for the development of new Alzheimer’s drugs and for detecting the disease before the onset of clinical symptoms.

A study published online March 21 in the Journal of Alzheimer’s Disease, for the first time demonstrates that the FKBP52 protein, discovered by Prof. Etienne BAULIEU twenty years ago, may prevent hyperphosphorylation of Tau protein, which has been shown to characterise a number of cerebral neurodegenerative diseases, including Alzheimer’s Disease (AD).

This work has been carried out by Professor Etienne Baulieu and his research team at Inserm (National Institute for medical research in France) with the support of philanthropists who help the Institut Baulieu, based in France.

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Antioxidant supplements ineffective against Alzheimer’s, study shows

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For years, doctors have touted an antioxidant-rich diet to help stave off memory loss and dementia. A new study says antioxidants may not do much for preventing Alzheimer’s after all.

An antioxidant cocktail of vitamin E, vitamin C, and lipoic acid had no effect on reducing the physical signs and cognitive decline seen in Alzheimer’s disease, the study found.

Antioxidants are found in apples, blueberries, cranberries, pomegranates, strawberries and other types of fruit. Earlier research suggests a diet rich in antioxidants boosts memory and prevent age-related memory loss. They’re thought to work by protecting cells against free radicals, which are single molecules that latch onto a cell and cause damage. Antioxidants are also thought to have a protective benefit against cancer and heart disease.

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Researchers find way to predict disease in people with a rare form

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Remembering family members who can’t remember themselves, Alexandra looks through pictures of several relatives struck with an aggressive form of Alzheimer’s disease.

The 35-year-old woman, who will be identified as Alexandra to protect her identity, lost her mother to familial Alzheimer’s. Her mother was diagnosed with the disease at age 42 and died in her early 50s.

“It’s sad, and the sadder part about it is she didn’t have a life that she should have deserved,” Alexandra said.

Like other relatives, Alexandra’s mother died from familial Alzheimer’s in her early 50s. Doctors say having the specific gene mutations predict with 100 percent certainty the carrier will develop the disease. While familial Alzheimer’s disease, or FAD, accounts for less than 2 percent of total cases, the disease process is similar to common forms.

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Alzheimer’s patients ‘should stay on drugs for longer’

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Thousands of patients with advanced Alzheimer’s disease could benefit from drugs, research suggests.

A study in the the New England Journal of Medicine found that patients who stayed on the dementia drug Aricept had a slower decline in their memory.

The drug tends not to be prescribed once sufferers progress beyond moderate symptoms.

Medicines regulator NICE said its guidelines supported continuing treatment where there were benefits.

The patent for the medicine Aricept, which is used to treat Alzheimer’s disease, expired recently. Much cheaper versions under the generic name donepezil are already available for about £12 a month.

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Chemical link revealed in Alzheimer’s study

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Alzheimer’s symptoms such as memory loss could be prevented by
targeting a chemical that dismantles brain connections, research
suggests.

Scientists have already started work searching for a drug that will block the mechanism, discovered in mice.

If successful, a treatment that effectively protects against the effects of Alzheimer’s could be available in the next 10 years.

It has long been known that the disease is linked to a build-up of toxic amyloid-beta protein in the brain.

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