Lithium levels tied to Alzheimer’s disease and dementia

Alzheimer; News from the web:

Levels of lithium were significantly reduced in the prefrontal cortex of people with mild cognitive impairment and Alzheimer’s disease (AD).

In a mouse model of AD, a low-dose lithium salt in the diet reversed memory loss and prevented cognitive decline in aging mice.

While more study is needed, lithium replacement could be a potential approach to prevent and treat AD.

Read all about it HERE

Rather Than Driving, Hop on a Bike

Alzheimer; News from the web:

Middle-aged men and women who opted to cycle or walk had a lower risk of developing dementia years later than their peers who rode in a car or took a bus, according to a new report.

Read all about it HERE

Exercise targets specific brain cells to protect against Alzheimer’s

Alzheimer; News from the web:

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer’s disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise. These findings, which were validated in samples from people, shed light on the connection between exercise and brain health and point to future drug targets. Results are published in Nature Neuroscience. 

Read all about it HERE

Potential new treatment for Alzheimer’s disease, other neurodegenerative conditions

Investigators at Case Western Reserve UniversityUniversity Hospitals and the Louis Stokes Cleveland VA Medical Center have identified a new and promising drug to treat AD.

The drug—and their approach by identifying a new target in the brain—showed promising results in mouse models of AD. Their findings were reported in a study published May 21 in the scientific journal Proceedings of the National Academy of Sciences (PNAS).

“Our findings suggest an effective new way to safely prevent neurodegeneration and cognitive impairment in Alzheimer’s disease by directly protecting the blood-brain barrier (BBB),” said the study’s co-lead researcher Andrew Pieper, a psychiatrist and neuroscientist, the Case Western Reserve University Rebecca E. Barchas MD DLFAPA University Professor of Translational Psychiatry and the Morley-Mather Chair of Neuropsychiatry at University Hospitals Cleveland Medical Center.

Read the original article HERE

Clearing waste products in the brain may get easier

Alzheimer; News from the web:

NIH-supported research has identified a type of immune cell that helps remove waste products in the brain. Boosting these immune cells in aged mice improved the clearance of proteins associated with Alzheimer’s disease. The findings suggest potential prevention and treatment strategies for Alzheimer’s disease and related disorders.

Read all about it HERE