‘Potentially Scary’ Link Between Alzheimer’s, Nose Picking Revealed

Researchers are investigating a “potentially scary” link between nose picking and Alzheimer’s disease.

Dirty fingers introduce bacteria into the nose, resulting in infections that could lead to crusting, tissue damage and nosebleeds and now scientists are testing the theory that trauma to the nasal lining may transmit germs to the brain, possibly resulting in inflammation and amyloid plaques being formed, in line with the progressive neurodegenerative condition. Researchers have never been able to pinpoint the exact cause of Alezheimer’s which gradually impairs various brain function such as memory, thinking, reasoning and judgment, and some have shifted their focus to the crucial nose-brain axis, the pathway between the nasal cavity and central nervous system.

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new study is first step in reversing Alzheimer’s

A diagnosis of Alzheimer’s changes everything.

The brain function begins to decline until it just doesn’t work anymore.

It’s a slow decline that takes a toll not only on the patient but the people who love them.

A new study from a team at University Hospitals hopes to be a first step in reversing the disease. It all started with research in one one of the leading risk factors for Alzheimer’s: traumatic brain injury.

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Lithium levels tied to Alzheimer’s disease and dementia

Alzheimer; News from the web:

Levels of lithium were significantly reduced in the prefrontal cortex of people with mild cognitive impairment and Alzheimer’s disease (AD).

In a mouse model of AD, a low-dose lithium salt in the diet reversed memory loss and prevented cognitive decline in aging mice.

While more study is needed, lithium replacement could be a potential approach to prevent and treat AD.

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Rather Than Driving, Hop on a Bike

Alzheimer; News from the web:

Middle-aged men and women who opted to cycle or walk had a lower risk of developing dementia years later than their peers who rode in a car or took a bus, according to a new report.

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Exercise targets specific brain cells to protect against Alzheimer’s

Alzheimer; News from the web:

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer’s disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise. These findings, which were validated in samples from people, shed light on the connection between exercise and brain health and point to future drug targets. Results are published in Nature Neuroscience. 

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Potential new treatment for Alzheimer’s disease, other neurodegenerative conditions

Investigators at Case Western Reserve UniversityUniversity Hospitals and the Louis Stokes Cleveland VA Medical Center have identified a new and promising drug to treat AD.

The drug—and their approach by identifying a new target in the brain—showed promising results in mouse models of AD. Their findings were reported in a study published May 21 in the scientific journal Proceedings of the National Academy of Sciences (PNAS).

“Our findings suggest an effective new way to safely prevent neurodegeneration and cognitive impairment in Alzheimer’s disease by directly protecting the blood-brain barrier (BBB),” said the study’s co-lead researcher Andrew Pieper, a psychiatrist and neuroscientist, the Case Western Reserve University Rebecca E. Barchas MD DLFAPA University Professor of Translational Psychiatry and the Morley-Mather Chair of Neuropsychiatry at University Hospitals Cleveland Medical Center.

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