Scientists have recently made a major discovery that could lead to a breakthrough in the treatment of Alzheimer’s disease. A recent study published in Nature Medicine reports that researchers were able to identify the primary genetic risk factor the development of the disease, and they even figured out a potential way to neutralize the risk factor.
Government and other scientists are proposing a new way to define Alzheimer’s disease — basing it on biological signs, such as brain changes, rather than memory loss and other symptoms of dementia that are used today.
Research from the University of Texas at San Antonio suggests that the plaques that cause the symptoms of Alzheimer’s disease may be more complicated than previously believed, a finding that could significantly affect drug development for the disease.
Researchers found that in addition to the sticky proteins called amyloid beta, other neural and repair proteins also exist within the plaques, indicating new biomarkers for the disease that affects more than 5 million people in the United States.
Most people associate dementia with short-term memory loss; someone with the condition can’t remember the prime minister’s name or where they left their car keys. But that inability to recall simple facts is not the only early sign of dementia, says Dr Selina Wray, Alzheimer’s Research UK senior research fellow and winner of the Alzheimer’s Research UK David Hague Early Career Investigator of the Year Award 2018.
Spotting the first indications of Alzheimer’s years before any obvious symptoms come on could help pinpoint people most likely to benefit from experimental drugs and allow family members to plan for eventual care. Devices equipped with such algorithms could be installed in people’s homes or in long-term care facilities to monitor those at risk. For patients who already have a diagnosis, such technology could help doctors make adjustments in their care.
The device works very similar to a pacemaker that is used in heart patients, except the wires go to a specific section of the brain. The wires stimulate “sickish” cells in the brain and help to restore functionality.
University of Minnesota researchers have created new technology aimed at making it easier to detect the early stages of Alzheimer’s disease.
Researchers from the Center for Drug Design used a camera to gather images of light interacting with the retina, which can catch Alzheimer’s in its early stages, the Minnesota Daily reported.
“Our goal is to detect the disease as early as we can, which will help in the progression and the success of treatments as well as drug discovery,” said Swati More, a university professor and co-lead researcher on the project.
A simple new tool that tracks cognitive performance in adults aims to help physicians identify people who may be on the path to Alzheimer disease or another form of dementia. The tool, called the QuoCo (cognitive quotient), is published in CMAJ (Canadian Medical Association Journal).
……..It’s not always bad. There’s good research on this about happiness and diagnoses. When people get diagnosed with a chronic terminal medical condition, oftentimes their mood can decrease, but if you give it enough time, usually they kind of bounce back a little bit – they start to cope with this,……
It’s one of the holy grails of science: a cure for Alzheimer’s. Currently, there is no treatment to stop the disease, let alone slow its progression. And billionaire Bill Gates thinks he will change that.
“I believe there is a solution,” he told me without hesitation.
Ionis and Biogen are bringing to bear the Ionis drug technology called antisense, which targets diseases processes at the genetic level. It blocks or modifies production of proteins involved in disease.
The Phase 1/2a study of the Alzheimer’s drug, IONIS-MAPTRx, seeks evidence of safety and signs of activity. It’s to be given in 44 patients with mild Alzheimer’s over three months.The drug targets microtubule-associated tau protein, also called MATP, or tau, an abnormal protein associated with Alzheimer’s.
“Alzheimer’s disease starts in the brain more than twenty years before the first symptom,” said Richard Isaacson, director of the Alzheimer’s Prevention Clinic at New York-Presbyterian/Weill-Cornell Medical Center. “Alzheimer’s disease is not an older person’s disease. It’s a disease of younger and middle-aged people. And that’s how we have to shift the paradigm.”
While memory loss is an early symptom of Alzheimer’s disease, its presence doesn’t mean a person will develop dementia. A new study has found a clinically useful way to predict who won’t develop Alzheimer’s disease, based on patients’ awareness of their memory problems.
During the holidays, families come together from near and far to celebrate the season. Often it is also a time when family members begin to notice subtle changes in loved ones that were not apparent before.
Scientists have recently uncovered some surprising early symptoms, beyond memory loss or confusion while driving. Now, research published in the journal Annals of Neurology says that one marker for Alzheimer’s disease could be written all over your face, too.
In what they call “a major advancement,” researchers at Cedars-Sinai Medical Center in Los Angeles found that a noninvasive eye scan could help detect Alzheimer’s disease earlier than expensive and invasive brain scans, Sean Rossman reports in USA Today. Researchers say the scans can find buildups of toxic proteins in the retina like those associated with Alzheimer’s. Researchers hope the scans eventually will lead to earlier detection of the disease and enable medical professionals to help patients “change the course of the disorder with medications and lifestyle changes,” says Keith L. Black, chair of the Cedars-Sinai Department of Neurosurgery.
In the largest and most conclusive study of its kind, researchers have analysed blood samples to create a novel and non-invasive way of helping to diagnose Alzheimer’s disease and distinguishing between different types of neurodegenerative disorders.
Following this breakthrough discovery, Alzheimer’s sufferers may now have an additional test to improve the accuracy of diagnosis in order to better tailor appropriate treatment. The research also offers a valuable opportunity to monitor the disease.