Long before the tell-tale signs of Parkinson’s disease appear, including tremors and muscle stiffness, there are other, more subtle signs of the disease.

These include changes in oral pronunciation and language and difficulties breathing or swallowing.

People with Alzheimer’s disease can also experience a reduction in their vocabulary and a tendency to repeat certain words. These also appear well before there is clear memory loss.

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Diagnoses of cognitive impairment and dementia should be based on symptoms and functional effects rather than biomarkers, argued a speaker at Internal Medicine Meeting 2026.

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You may have heard that diabetes and Alzheimer’s disease are linked. This connection can sound concerning, especially if you are living with diabetes. But understanding what the research shows can help separate facts from myths, and help you focus on what supports long‑term health. Credentialled Diabetes Educator and Registered Nurse, Carolien Koreneff, explains.

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Alzheimer’s research is entering a new phase, as treatments that have taken decades to develop begin to reach patients. But getting those advances to people will depend on more than scientific progress alone, according to pioneering Alzheimer’s researcher John Hardy.

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Key Takeaways

• Timely and accurate Alzheimer’s disease (AD) diagnosis is critical for access to care planning, including potential treatment with disease-modifying therapies.
• Strong patient-provider partnerships can enable timely assessment and treatment.
• AD blood tests are expanding access to help aid in a timely diagnosis.
• Amyloid-targeting therapies (ATTs) can help slow cognitive decline in patients with early symptomatic AD.
• Early intervention and shared decision-making empower patients and can improve real-world outcomes.

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Alzheimer’s disease may begin its biological progression far earlier than symptoms suggest, with subtle shifts in brain and blood markers emerging decades in advance.

Scientists are uncovering a hidden phase of Alzheimer’s disease that may begin far earlier than most people realize. Long before memory loss becomes noticeable, subtle biological changes could already be underway — potentially starting in a person’s late 50s, according to new research from Mayo Clinic.

The study, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, tracks when key changes in the brain and blood begin to speed up over a person’s lifetime. The findings offer clues about the most effective timing for detection and prevention efforts.

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