• A 10-year study showed that APOE e4 carriers experience faster cognitive decline than APOE e2 and e3 carriers.
• Greater walking time appeared to benefit cognitive performance for female APOE e2 and e3 carriers.
• In males, walking time and APOE status were not as strongly associated with cognition.
• Maintaining walking time over 10 years was associated with slower cognitive decline among APOE e4 carriers.

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