Even one fall by an older adult is just as accurate in predicting cognitive decline as individuals with elevated amyloid, the Alzheimer’s brain protein considered the gold standard for gauging Alzheimer’s dementia risk, according to a new study.
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At the American Glaucoma Society (AGS) 2026 Annual Meeting, Thomas Johnson, MD, PhD, explored the epidemiological and pathophysiological overlaps between glaucoma and Alzheimer’s disease in a talk entitled “The Neurodegeneration Spectrum: Glaucoma and Alzheimer’s Disease.” In it, he highlighted similarities between these two neurodegenerative diseases and explained how insights from each condition could help advance the understanding of the other.
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In January 2023, neurologists at Beijing’s Xuanwu Hospital of Capital Medical University published a case study that briefly unsettled everything the field thought it knew about Alzheimer’s disease. Two years later, as new treatments and updated diagnostic criteria reshape how the disease is understood, the questions it raised are still unanswered.
He started forgetting things when he was 17. He couldn’t recall what had happened the day before, couldn’t follow what he’d just read, struggled to retain anything new. By 19, the decline had progressed enough that he withdrew from high school. He could still live independently, but something was clearly wrong.
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Staying mentally engaged throughout life may lower your risk of developing Alzheimer’s disease in old age, according to a new analysis. The study found that people who pursue lifelong learning activities like reading and writing or learning a new language had a lower risk of Alzheimer’s disease. They also showed slower declines in memory and thinking skills as they aged.
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WashU Medicine researchers developed a model to estimate when Alzheimer’s disease symptoms will begin based on the accumulation of amyloid and tau proteins in the brain. These proteins build up predictably over time, like tree rings, providing scientists with a clock for Alzheimer’s symptoms.
Researchers at Washington University School of Medicine in St. Louis have developed a method to predict when someone is likely to develop symptoms of Alzheimer’s disease using a single blood test.
In a new study published Feb. 19 in Nature Medicine, the researchers demonstrated that their models predicted the onset of Alzheimer’s symptoms within a margin of three to four years. This could have implications both for clinical trials developing preventive Alzheimer’s treatments and for eventually identifying individuals likely to benefit from these treatments.
Researchers have long recognized that Alzheimer’s disease is marked by abnormal plaques and tangled proteins in the brain. More recently, attention has turned to the brain’s blood vessels and how problems in the vascular system may influence the course of the disease. Even with decades of discoveries, however, these insights have not yet led to treatments that fully stop or reverse Alzheimer’s. A major reason is that scientists still do not have a complete picture of how brain cells progressively break down over time.
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