Alzheimer; News from the web:
Levels of lithium were significantly reduced in the prefrontal cortex of people with mild cognitive impairment and Alzheimer’s disease (AD).
In a mouse model of AD, a low-dose lithium salt in the diet reversed memory loss and prevented cognitive decline in aging mice.
While more study is needed, lithium replacement could be a potential approach to prevent and treat AD.
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Alzheimer; News from the web:
Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer’s disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise. These findings, which were validated in samples from people, shed light on the connection between exercise and brain health and point to future drug targets. Results are published in Nature Neuroscience.
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Alzheimer; News from the web:
Family members remember some of the early signs of Alzheimer’s in their loved ones quite well. This type of dementia often begins with struggles in communication, lapses in memory, and confusion around everyday problem-solving.
But scientists are now uncovering evidence of another early signal — mood disorders, like depression and bipolar disorder, that begin later in life. While a link between these conditions and Alzheimer’s has long been suspected, what’s been missing is a clear understanding of how the two connect in the brain.
That’s starting to change. A research team from Japan’s National Institutes for Quantum Science and Technology (QST) recently found significant amounts of tau protein — a hallmark of Alzheimer’s — in the brains of people with late-life mood disorders (LLMDs). Their study, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, suggests that these psychiatric symptoms might serve as a warning sign for neurodegenerative disease.
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Alzheimer; News from the web:
A compound found in the gut may reduce some of the manifestations of Alzheimer’s disease, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.
While mounting evidence has pointed to a connection between the gut microbiome and the degenerative effects of Alzheimer’s disease, the mechanisms are not well understood, said Robert Vassar, PhD, the Davee Professor of Alzheimer Research and professor of Neurology and director of the Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, who was senior author of the study.
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Alzheimer; News from the web:
Now doctors have a new tool: an Alzheimer’s blood test. The Food and Drug Administration recently approved the first test that uses a blood sample to help diagnose Alzheimer’s disease. The disease, which causes a decline in memory and thinking skills, affects nearly 7 million Americans—and is projected to become more prevalent.
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Investigators at Case Western Reserve University, University Hospitals and the Louis Stokes Cleveland VA Medical Center have identified a new and promising drug to treat AD.
The drug—and their approach by identifying a new target in the brain—showed promising results in mouse models of AD. Their findings were reported in a study published May 21 in the scientific journal Proceedings of the National Academy of Sciences (PNAS).
“Our findings suggest an effective new way to safely prevent neurodegeneration and cognitive impairment in Alzheimer’s disease by directly protecting the blood-brain barrier (BBB),” said the study’s co-lead researcher Andrew Pieper, a psychiatrist and neuroscientist, the Case Western Reserve University Rebecca E. Barchas MD DLFAPA University Professor of Translational Psychiatry and the Morley-Mather Chair of Neuropsychiatry at University Hospitals Cleveland Medical Center.
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