Alzheimer’s Might Not Actually Be a Brain Disease, Reveals Expert

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Based on our past 30 years of research, we no longer think of Alzheimer’s as primarily a disease of the brain. Rather, we believe that Alzheimer’s is principally a disorder of the immune system within the brain.

The immune system, found in every organ in the body, is a collection of cells and molecules that work in harmony to help repair injuries and protect from foreign invaders.

When a person trips and falls, the immune system helps to mend the damaged tissues. When someone experiences a viral or bacterial infection, the immune system helps in the fight against these microbial invaders.

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Alzheimer’s reversible? Regulating molecule in brain is key, doctor says

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Alzheimer’s may be reversible if levels of a molecule known as NAD+ can be regulated in the brain, according to a researcher who helped test the approach in mice.

In a study published last month, scientists said they were able to use pharmacology to reverse advanced Alzheimer’s in mice that had been genetically programmed to develop the disease.

Researchers said they achieved this by stabilizing the levels of NAD+ (nicotinamide adenine dinucleotide) — an energy-producing chemical that is low in human Alzheimer’s patients — within the brains of lab animals.

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Increased Levels of a Protein Linked to Alzheimer’s Found in Some With Long COVID

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A study of 227 individuals who experienced neuro cognitive difficulties post COVID-19 infection – such as headaches, vertigo, balance dysregulation, changes in taste/smell, and brain fog – displayed a significant increase in their blood plasma of a crucial protein called tau, which is found in nerves and especially in the brain. Excess levels of tau are linked to neurodegenerative diseases and found in many Alzheimer’s patients.

Read more about this study HERE

What Our Body Clocks May Say About Our Alzheimer’s Risk

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Our circadian rhythms, the internal body clock that determines when we are most active and alert and when we wind down and go to sleep during a typical 24-hour day, may play a role in our risk of dementia, according to a new report. The study found that people with less regular circadian rhythms, as well as those whose activity levels peaked later in the afternoon, were at increased risk of developing Alzheimer’s disease and other forms of dementia.

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‘Potentially Scary’ Link Between Alzheimer’s, Nose Picking Revealed

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Researchers are investigating a “potentially scary” link between nose picking and Alzheimer’s disease.

Dirty fingers introduce bacteria into the nose, resulting in infections that could lead to crusting, tissue damage and nosebleeds and now scientists are testing the theory that trauma to the nasal lining may transmit germs to the brain, possibly resulting in inflammation and amyloid plaques being formed, in line with the progressive neurodegenerative condition. Researchers have never been able to pinpoint the exact cause of Alezheimer’s which gradually impairs various brain function such as memory, thinking, reasoning and judgment, and some have shifted their focus to the crucial nose-brain axis, the pathway between the nasal cavity and central nervous system.

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Early prediction of Alzheimer’s disease using longitudinal electronic health records of US military veterans

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This study explored whether early signs of Alzheimer’s disease could be detected in routine medical records. We analyzed the health records of over 295,000 people from the U.S. Veterans Health Administration. We focused on words in doctors’ notes that reflect a wide range of early symptoms, including changes in memory, speech, cognition, mood, physical functioning, and daily activity needs. These signs appeared more frequently and increased more rapidly in people who were later diagnosed with Alzheimer’s. A computer model built on these words was able to predict who might develop the disease years in advance. These findings suggest that ordinary clinical notes could help doctors notice early warning signs of Alzheimer’s and support earlier care and planning.

Read more about this HERE