Alzheimer; News from the web:
Middle-aged men and women who opted to cycle or walk had a lower risk of developing dementia years later than their peers who rode in a car or took a bus, according to a new report.
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Alzheimer; News from the web:
There is no cure for Alzheimer’s disease, but medication can help manage the condition. Currently, the main drugs used to treat Alzheimer’s are what’s known as symptomatic therapies, meaning they ease symptoms but don’t address the cause of the disease. These include cholinesterase inhibitors and memantine. A more recent entry into the field, lecanemab, may help slow the progression of the disease. Here’s a look at how these medications work.
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Alzheimer; News from the web:
A groundbreaking study suggests that the immune molecule STING may play a critical role in Alzheimer’s and other neurodegenerative diseases by exacerbating brain inflammation and damage. Blocking STING in lab models protected against cognitive decline, opening a promising new path for therapeutic development.
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Alzheimer; News from the web:
Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer’s disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise. These findings, which were validated in samples from people, shed light on the connection between exercise and brain health and point to future drug targets. Results are published in Nature Neuroscience.
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Alzheimer; News from the web:
Alzheimer’s disease develops slowly and silently, with biological changes in the brain beginning many years before any symptoms appear. A new study from researchers at the UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND) shows that we may be able to identify those most at risk using two simple and widely accessible tools: a blood test and a brief unsupervised memory assessment.
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Alzheimer; News from the web:
Family members remember some of the early signs of Alzheimer’s in their loved ones quite well. This type of dementia often begins with struggles in communication, lapses in memory, and confusion around everyday problem-solving.
But scientists are now uncovering evidence of another early signal — mood disorders, like depression and bipolar disorder, that begin later in life. While a link between these conditions and Alzheimer’s has long been suspected, what’s been missing is a clear understanding of how the two connect in the brain.
That’s starting to change. A research team from Japan’s National Institutes for Quantum Science and Technology (QST) recently found significant amounts of tau protein — a hallmark of Alzheimer’s — in the brains of people with late-life mood disorders (LLMDs). Their study, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, suggests that these psychiatric symptoms might serve as a warning sign for neurodegenerative disease.
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