Category Archives: Treatment

Scientists Discover Brain-Penetrating Compounds That May Calm Alzheimer’s-Linked Inflammation

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Researchers have created a targeted compound that blocks an enzyme linked to inflammation in individuals with a genetic predisposition to Alzheimer’s disease, while still maintaining normal brain activity and successfully passing through the blood-brain barrier.

Scientists at the University of Southern California report that they have found new druglike compounds that could calm a major source of brain inflammation tied to Alzheimer’s disease. The study was just published in the Nature journal npj Drug Discovery.

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Groundbreaking study shows Alzheimer’s may be reversible in advanced stages

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Cleveland researchers achieve full cognitive recovery in mice, offering new hope for dementia patients.

Dr. Andrew Pieper, director of the Brain Health Medicines Center at University Hospitals and senior author of the study, emphasizes this represents a fundamental shift in understanding the disease. “The key takeaway is a message of hope – the effects of Alzheimer’s disease may not be inevitably permanent,” Pieper explained. “The damaged brain can, under some conditions, repair itself and regain function.”

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Alzheimer’s Might Not Actually Be a Brain Disease, Reveals Expert

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Based on our past 30 years of research, we no longer think of Alzheimer’s as primarily a disease of the brain. Rather, we believe that Alzheimer’s is principally a disorder of the immune system within the brain.

The immune system, found in every organ in the body, is a collection of cells and molecules that work in harmony to help repair injuries and protect from foreign invaders.

When a person trips and falls, the immune system helps to mend the damaged tissues. When someone experiences a viral or bacterial infection, the immune system helps in the fight against these microbial invaders.

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Alzheimer’s reversible? Regulating molecule in brain is key, doctor says

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Alzheimer’s may be reversible if levels of a molecule known as NAD+ can be regulated in the brain, according to a researcher who helped test the approach in mice.

In a study published last month, scientists said they were able to use pharmacology to reverse advanced Alzheimer’s in mice that had been genetically programmed to develop the disease.

Researchers said they achieved this by stabilizing the levels of NAD+ (nicotinamide adenine dinucleotide) — an energy-producing chemical that is low in human Alzheimer’s patients — within the brains of lab animals.

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Drugs for Alzheimer’s disease

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Alzheimer; News from the web:

There is no cure for Alzheimer’s disease, but medication can help manage the condition. Currently, the main drugs used to treat Alzheimer’s are what’s known as symptomatic therapies, meaning they ease symptoms but don’t address the cause of the disease. These include cholinesterase inhibitors and memantine. A more recent entry into the field, lecanemab, may help slow the progression of the disease. Here’s a look at how these medications work.

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Exercise targets specific brain cells to protect against Alzheimer’s

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Alzheimer; News from the web:

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer’s disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise. These findings, which were validated in samples from people, shed light on the connection between exercise and brain health and point to future drug targets. Results are published in Nature Neuroscience. 

Read all about it HERE