Status of Alzheimer’s research

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There are roughly 326 active, recruiting or enrolling by invitation clinical trials on the elusive disease, per clinicaltrial.gov. The U.S. last year dramatically stepped up funding for Alzheimer’s disease research, from $400 million a year to over $2 billion annually, although the Alzheimer’s Association says more is needed.

The biggest problem: Scientists still don’t know the cause of Alzheimer’s.

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Risk of Alzheimer’s when it hits extended family members

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In line with previous studies, the researchers found that having one or more first-degree relatives with Alzheimer’s put people at significantly higher risk for the disease. People with one first-degree relative with Alzheimer’s were 1.73 times more likely to develop the disease. Looking further into the family tree, people with two first-degree relatives with Alzheimer’s were nearly four times more likely to develop the disease. Those with three first-degree relatives were nearly two-and-half more times likely, and those with four were almost 15 times more likely to develop Alzheimer’s disease.

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Mysterious dementia that mimics Alzheimer’s

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A newly described dementia strikes people in their last decades of life. The disease, aptly named LATE, comes with symptoms that resemble Alzheimer’s disease, but is thought to be caused by something completely different.

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Accelerating Alzheimer’s research

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A team of researchers at the Human Computation Institute and Cornell University seek to understand what causes a 30% reduction of blood flow to the brain in Alzheimer’s patients.

Preliminary findings from the Schaffer-Nishimura Biomedical Engineering Lab suggest that restoring blood flow to the brain could delay the onset of Alzheimer’s and restore cognitive functioning. But there is too much data to sift through, and the blood flow imagery is too subtle for most algorithms to classify into capillaries that are either flowing or stalled. So instead, citizen scientists are helping analyze the videos in a gamified effort called “Stall Catchers” — and, through this crowdsourcing effort, are doing so at a much faster rate than the lab.

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Play the game to help research HERE

Light on Alzheimer’s

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In 2016, to the surprise of Alzheimer’s disease researchers across the world, a team at the Massachusetts Institute of Technology found that setting mice in front of a blinking light could clear out the characteristic protein plaques thought to be one of the roots of the disease. A recent follow up study found that sounds played at a particular frequency clearned plaques and improved cognition, as well.

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