Category Archives: Research

Compound Produced by Gut Bacteria May Slow Alzheimer’s Progression

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A compound found in the gut may reduce some of the manifestations of Alzheimer’s disease, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

While mounting evidence has pointed to a connection between the gut microbiome and the degenerative effects of Alzheimer’s disease, the mechanisms are not well understood, said Robert Vassar, PhD, the Davee Professor of Alzheimer Research and professor of Neurology and director of the Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, who was senior author of the study.

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FDA Approves First Blood Test for Alzheimer’s Disease

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Now doctors have a new tool: an Alzheimer’s blood test. The Food and Drug Administration recently approved the first test that uses a blood sample to help diagnose Alzheimer’s disease. The disease, which causes a decline in memory and thinking skills, affects nearly 7 million Americans—and is projected to become more prevalent.

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Potential new treatment for Alzheimer’s disease, other neurodegenerative conditions

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Investigators at Case Western Reserve University, University Hospitals and the Louis Stokes Cleveland VA Medical Center have identified a new and promising drug to treat AD.

The drug—and their approach by identifying a new target in the brain—showed promising results in mouse models of AD. Their findings were reported in a study published May 21 in the scientific journal Proceedings of the National Academy of Sciences (PNAS).

“Our findings suggest an effective new way to safely prevent neurodegeneration and cognitive impairment in Alzheimer’s disease by directly protecting the blood-brain barrier (BBB),” said the study’s co-lead researcher Andrew Pieper, a psychiatrist and neuroscientist, the Case Western Reserve University Rebecca E. Barchas MD DLFAPA University Professor of Translational Psychiatry and the Morley-Mather Chair of Neuropsychiatry at University Hospitals Cleveland Medical Center.

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Clearing waste products in the brain may get easier

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NIH-supported research has identified a type of immune cell that helps remove waste products in the brain. Boosting these immune cells in aged mice improved the clearance of proteins associated with Alzheimer’s disease. The findings suggest potential prevention and treatment strategies for Alzheimer’s disease and related disorders.

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New genes identified, new options for treatment

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Researchers have discovered two novel genes that increase an individual’s risk of developing Alzheimer’s disease. The researchers used a technique called exome sequencing to identify the genes. Exome sequencing is able to identify rare mutations. The discovery brings scientists closer to finding treatment options and preventative measures for the disease.

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