Category Archives: Prevention

Chile has a dementia plan

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Alzheimer; News from the web:

The government of Chile has adopted a national plan on dementia following consultation with Corporación Alzheimer Chile and other key stakeholders. The plan is the 30th to be adopted worldwide, and includes key targets for improving awareness, access to care, support and treatment, research and risk reduction of dementia by 2025.
It is estimated that 180,000 people are living with dementia in Chile. The plan follows the publication of existing plans in Argentina, Costa Rica, Cuba, Mexico, Puerto Rico, Uruguay and the USA, and includes a budget of USD $5.5m a year for implementation.

Read all about it HERE

Alzheimer’s on the spectrum

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Dr. Gayatri Devi, neurologist at New York’s Lenox Hill Hospital, is out with a new book that defines Alzheimer’s as a spectrum disorder. She argues, among other things, that 60% of the Alzheimer’s cases can be prevented. See the video in the link for today.

Read all about it HERE

Israeli researchers may have found a trigger!

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Alzheimer; News from the web:

Dr. Debbie Toiber, of the BGU Department of Life Sciences, and her team discovered that a specific protein — Sirtuin-6 (SIRT6) — is severely reduced in the brains of Alzheimer’s patients. SIRT6 is critical to the repair of DNA, the deterioration of which “is the beginning of the chain that ends in neurodegenerative diseases in seniors,” she explains.

The blood-brain barrier prevents us from simply being able to inject the protein into the brain to replenish its supply. Dr. Toiber is currently working on finding a way to increase the expression of the protein into the brain.

Read all about it HERE

Four trials go to human phase!

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Ionis and Biogen are bringing to bear the Ionis drug technology called antisense, which targets diseases processes at the genetic level. It blocks or modifies production of proteins involved in disease.

The Phase 1/2a study of the Alzheimer’s drug, IONIS-MAPTRx, seeks evidence of safety and signs of activity. It’s to be given in 44 patients with mild Alzheimer’s over three months.The drug targets microtubule-associated tau protein, also called MATP, or tau, an abnormal protein associated with Alzheimer’s.

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Alzheimer’s is a young or middle-aged person’s disease

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Alzheimer; News from the web:

“Alzheimer’s disease starts in the brain more than twenty years before the first symptom,” said Richard Isaacson, director of the Alzheimer’s Prevention Clinic at New York-Presbyterian/Weill-Cornell Medical Center. “Alzheimer’s disease is not an older person’s disease. It’s a disease of younger and middle-aged people. And that’s how we have to shift the paradigm.”

Read all about it HERE