Alzheimer; News from the web:

Nearly three dozen new Alzheimer’s drugs may reach the market in the next five years, researchers say.

That includes 27 drugs in phase 3 clinical trials, which are later in the drug review process. It also includes eight drugs in phase 2 clinical trials, according to an analysis by ResearchersAgainstAlzheimer’s (RA2) investigators, an UsAgainstAlzheimer’s network.

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Heartburn meds are not a problem for Alzheimer’s after all

Alzheimer; News from the web:

Drugs used to treat acid reflux and ulcers don’t appear to boost the risk of dementia, as has been previously suspected, new research suggests.

The study focused on widely used proton pump inhibitors (PPIs) drugs — medicines such as Prevacid, Prilosec and Nexium. Previous studies have suggested the drugs may increase the risk of dementia and Alzheimer’s disease in people aged 75 and older.

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Accelerating drug discovery for Alzheimer’s

Alzheimer; News from the web:

An InSysBio scientific group led by Tatiana Karelina has developed a quantitative system pharmacology model of Alzheimer’s disease. The first part has been published in CPT Pharmacometrics & Systems Pharmacology, and shows how to design initial phases of clinical trials of new drugs and to interpret the data.

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Maybe we need a mix of drugs to fight Alzheimer’s

Alzheimer; News from the web:

This could increase the pace of finding a cure. Researchers are looking at how HIV got brought mostly under control:

The Alzheimer’s Association has partnered with the Alzheimer’s Drug Discovery Foundation (ADDF) to challenge the research community to propose promising drug combinations to find more-effective treatments.

The joint effort, known as the Alzheimer’s Combination Therapy Opportunities (ACTO) grant initiative, will provide $2 million this year for testing approaches that simultaneously target two or more processes believed to underlie, exacerbate, or occur in the disease.

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