Category Archives: Alzheimer Overview

Israeli researchers may have found a trigger!

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Alzheimer; News from the web:

Dr. Debbie Toiber, of the BGU Department of Life Sciences, and her team discovered that a specific protein — Sirtuin-6 (SIRT6) — is severely reduced in the brains of Alzheimer’s patients. SIRT6 is critical to the repair of DNA, the deterioration of which “is the beginning of the chain that ends in neurodegenerative diseases in seniors,” she explains.

The blood-brain barrier prevents us from simply being able to inject the protein into the brain to replenish its supply. Dr. Toiber is currently working on finding a way to increase the expression of the protein into the brain.

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Four trials go to human phase!

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Ionis and Biogen are bringing to bear the Ionis drug technology called antisense, which targets diseases processes at the genetic level. It blocks or modifies production of proteins involved in disease.

The Phase 1/2a study of the Alzheimer’s drug, IONIS-MAPTRx, seeks evidence of safety and signs of activity. It’s to be given in 44 patients with mild Alzheimer’s over three months.The drug targets microtubule-associated tau protein, also called MATP, or tau, an abnormal protein associated with Alzheimer’s.

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Alzheimer’s is a young or middle-aged person’s disease

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Alzheimer; News from the web:

“Alzheimer’s disease starts in the brain more than twenty years before the first symptom,” said Richard Isaacson, director of the Alzheimer’s Prevention Clinic at New York-Presbyterian/Weill-Cornell Medical Center. “Alzheimer’s disease is not an older person’s disease. It’s a disease of younger and middle-aged people. And that’s how we have to shift the paradigm.”

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A new Honorary Ambassador

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Alzheimer; News from the web:

The President of Costa Rica, Luis Guillermo Solís Rivera, has become an Honorary Ambassador of Alzheimer’s Disease International (ADI). The Vice President of the Republic of Costa Rica, Ms. Ana Helena Chacón Echeverría, recieved the award on behalf of the President, at a special meeting with Paola Barbarino, CEO of ADI and Juan Parra, Executive Director of

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