Alzheimer; News from the web:

The authors demonstrate, for the first time, that a modified strain of mice generated to display human-like symptoms of Alzheimer’s show significant cognitive improvements, including a reversal of spatial memory deficit, when the brain’s expression of p62 is restored.

The study further shows that the improvement is associated with reduced levels of Aβ and associated plaques in the brain. Finally, the new research describes the mechanism by which p62 activity improves Alzheimer’s disease symptoms in mice — by a process known as autophagy. The term refers to the degradation or disassembly of unnecessary or dysfunctional components of cells — a form of biological recycling essential for cellular health.

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