An NIH-funded research team, led by Drs. Orly Lazarov and Jalees Rehman at the University of Illinois, Chicago, turned to the brains of cognitive SuperAgers for clues. SuperAgers were defined as people at least 80 years old with memory test scores as good as or better than those of people in their 50s and 60s. The team looked for molecular signatures unique to those with exceptional recall and memory.

The findings give us a better understanding of cognitive function in the human brain as we age. “Determining why some brains age more healthily than others can help researchers make therapeutics that will boost memory in aging and prevent Alzheimer’s disease and related dementia,” Lazarov says.

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