Why do memories fade in Alzheimer’s disease – and can they be restored?

University of California, Irvine researchers have uncovered a key mechanism underlying memory loss, showing for the first time that dopamine dysfunction in the entorhinal cortex, a critical memory-related brain region, contributes directly to impaired memory formation.

The study, published today in Nature Neuroscience, identifies a previously unrecognized role for dopamine in Alzheimer’s-related cognitive decline and points to potential therapeutic strategies using existing drugs such as Levodopa.

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