Researchers have long recognized that Alzheimer’s disease is marked by abnormal plaques and tangled proteins in the brain. More recently, attention has turned to the brain’s blood vessels and how problems in the vascular system may influence the course of the disease. Even with decades of discoveries, however, these insights have not yet led to treatments that fully stop or reverse Alzheimer’s. A major reason is that scientists still do not have a complete picture of how brain cells progressively break down over time.

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