Catching Alzheimer’s Early

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Alzheimer’s disease develops slowly and silently, with biological changes in the brain beginning many years before any symptoms appear. A new study from researchers at the UC Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND) shows that we may be able to identify those most at risk using two simple and widely accessible tools: a blood test and a brief unsupervised memory assessment.

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Depression and Bipolar Disorder May Be Early Signs of Alzheimer’s

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Family members remember some of the early signs of Alzheimer’s in their loved ones quite well. This type of dementia often begins with struggles in communication, lapses in memory, and confusion around everyday problem-solving.

But scientists are now uncovering evidence of another early signal — mood disorders, like depression and bipolar disorder, that begin later in life. While a link between these conditions and Alzheimer’s has long been suspected, what’s been missing is a clear understanding of how the two connect in the brain.

That’s starting to change. A research team from Japan’s National Institutes for Quantum Science and Technology (QST) recently found significant amounts of tau protein — a hallmark of Alzheimer’s — in the brains of people with late-life mood disorders (LLMDs). Their study, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, suggests that these psychiatric symptoms might serve as a warning sign for neurodegenerative disease.

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Compound Produced by Gut Bacteria May Slow Alzheimer’s Progression

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A compound found in the gut may reduce some of the manifestations of Alzheimer’s disease, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

While mounting evidence has pointed to a connection between the gut microbiome and the degenerative effects of Alzheimer’s disease, the mechanisms are not well understood, said Robert Vassar, PhD, the Davee Professor of Alzheimer Research and professor of Neurology and director of the Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, who was senior author of the study.

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University of California San Diego Researchers Develop Gene Therapy Targeting Brain Cell Mechanisms in Alzheimer’s Disease

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Researchers at the University of California San Diego School of Medicine have developed a gene therapy for Alzheimer’s disease that aims to protect the brain from damage and preserve cognitive function. This approach differs from existing treatments, which primarily target unhealthy protein deposits in the brain. Instead, the new therapy focuses on addressing the root cause of Alzheimer’s by influencing how brain cells behave.

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FDA Approves First Blood Test for Alzheimer’s Disease

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Now doctors have a new tool: an Alzheimer’s blood test. The Food and Drug Administration recently approved the first test that uses a blood sample to help diagnose Alzheimer’s disease. The disease, which causes a decline in memory and thinking skills, affects nearly 7 million Americans—and is projected to become more prevalent.

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Alzheimer’s disease affects an organism as a whole

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While Alzheimer’s disease is mostly considered a disorder of the brain, emerging evidence suggests that the condition also affects other organs of the body. Working with the laboratory fruit fly, researchers at Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital (Duncan NRI) and collaborating institutions provide a new understanding of how Alzheimer’s disease affects different tissues across the entire body.

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